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Table 9 The correlation between the expression level of the studied genes and clinicopathological features of hepatocellular carcinoma cases

From: Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: Preliminary study

Reduced expression

Over expression

Variable

ISGF3G

TNF-α

VISA*

CDK-7

NOTCH4

BAX

Total: 17 (%)

13 (76)

15 (88)

14 (82)

12 (70)

11 (64)

13 (76)

Age (Mean ± SD)

(57 ± 10.2)

      

< 57 = 10(59)

8(80)

9(90)

8(80)

7(70)

7 (70)

8(80)

> 57 = 7(41)

5(71)

6(85)

6(85)

5(71)

4 (57)

5(71)

Gender

      

Male:13(76)

10(77)

12(92)

11(85)

10(77)

9(69)

11(85)

Female:4(24)

3(75)

3(75)

3(75)

2(50)

2(50)

2(50)

Tumor site

      

Rirht = 11(65)

9(82)

10(90)

8(73)

7(64)

6(55)

9(82)

Left = 6(35)

4(66)

5(83)

6(100)

5(83)

5(83)

4(66)

Tumor size

      

≤ 8 = 12(70)

10(83)

10(83)

11(91)

9(75)

8(66)

9 (75)

> 8 = 5(30)

3(60)

5(100)

3(60)

3(60)

5(100)

4 (80)

Grade

      

I+II = 14(82)

10(71)

13(93)

12(85)

10(71)

8(57)

10(71)

III = 3(18)

3(100)

2(66)

2(66)

2(66)

3(100)

3(100)

Safety margin

      

Pos 4 (24)

2(50)

3(75)

4(100)

3(75)

3(75)

3(75)

Neg 13(76)

11(85)

12(92)

10(77)

9(69)

8(61)

10(77)

Invasion

      

Pos 9 (53)

7(77)

8(88)

8(88)

8(88)

9(100)

6(66)

Neg 8(47)

6(75)

7(87)

6(75)

4(50)

2(25)

7(87)

Cirrhosis

      

Present: 10(59)

8(80)

9(90)

8(80)

7(70)

7(70)

9(90)

Absent: 7(41)

5(71)

6(85)

6(85)

5(71)

4(57)

4(57)

CAH

      

Pos: 9 (53)

7(77)

8(88)

7(77)

6(66)

6(66)

8(88)

Neg: 8(47)

6(75)

7(87)

7(87)

6(75)

5(63)

5(63)

  1. *VISA (also known as MAVS, IPS-I or CARDIF)