Figure 2

SSMD, Z -score and p-value of random samples of two paired differences corresponding to two siRNAs, siRNA A and siRNA B, respectively. Panels A1–A4 correspond to siRNA A and Panels B1–B4 correspond to siRNA B. Panels A1 and B1 display the population distributions of paired differences for siRNAs A and B respectively. Panels A2 and B2 show the appearance of random samples of the paired differences for siRNAs A and B respectively. "Diff.mean" and "Diff.sd" denote the mean and standard deviation of a paired difference respectively. In Panels A3 and B3, the blue (or green) points denote the t-values (or SSMD estimated values) of samples from siRNA A and siRNA B respectively; the orange lines denote the SSMD population values. In Panels A4 and B4, the blue points denote the p-values from t-test of testing paired difference mean and the red lines denote the cutoff of 0.01.