The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis

Table 2 Hydrogen bonds detected between Kit kinase & SH2 domains

Positions of residues in substrate (Donor: c-Kit)	Position of residues in Ligand (Acceptor: Shp-1)	Distance of H-bonds in A°
649:ND2	192:O	2.54
649:ND2	193:O	1.12
650:N	192:O	2.03
650:ND1	195:OE1	2.11
650:ND1	195:OE2	2.07
650:NE2	195:OE2	2.98
652:N	195:OE1	1.44
652:N	195:OE2	2.64
653:N	195:OE1	2.56
655:N	200:OD1	2.04
656:N	200:OD1	2.86
671:OE2	196:O	2.27
671:OE2	199:O	2.66
775:NE2	213:O	2.18
782:N	3:OG	2.12
785:OG	3:OG	2.52
785:OG	103:OD1	2.89
802:N	211:OE1	2.27
803:N	211:O	2.68
807:NZ	197:O	2.51
807:NZ	198:O	2.53
818:NZ	28:OG	2.51
818:NZ	100:O	2.83
819:ND2	100:OH	2.50
820:O	85:NE2	2.92
821:OG	82:O	2.03
847:OG1	83:OE1	2.83
847:OG1	83:OE2	2.09
848:N	83:OE2	2.84
849:N	83:OE2	2.19
849:OE2	79:O	2.58
849:OE2	83:OE1	2.49
849:OE2	83:OE2	1.91
915:N	76:OE2	2.49
916:OG1	75:O	2.71

A: Represents hydrogen bonds between activation loop residues and N-sh2 domain residues B: Shows kinase lobe residues preceding c-terminal tail of c-Kit and N-sh2 domain residues

ISSN: 1756-0500