Figure 1From: Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitatorsAverage hydropathy and similarity plots for Orai and CDF homologues. (A) Topological analyses of Orai protein homologues (see Table S1). The AveHAS program [28] was used to depict average hydropathy (top dark line) and average similarity (bottom light line) based on a ClustalX multiple alignment. The four conserved peaks of hydrophobicity, believed to correspond to the four TMSs, are labeled 1-4. (B) Topological analyses of CDF protein homologues (see [Additional file 5: Table S2]). The majority of CDF proteins contain six TMSs and correspond to the six conserved peaks labeled 1-6. Two roundworm members contain twelve TMSs (see text). The N-terminal 6 TMSs of these latter proteins are labeled 1'-6'. Position: alignment position in the multiple alignment.Back to article page