From: Factors of interrupting chemotherapy in patients with Advanced Non-Small-Cell Lung Cancer
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | |
ECOG Performance Status assessed by the physician | ||||||
0-1 >1 | 3.641 | [1.743-7.607] | 0.0006 | 3.279 | [1.546-6.955] | 0.0020 |
Hemoglobin | ||||||
Normal Abnormal† | 2.941 | [1.401-6.172] | 0.0044 | 2.781 | [1.290-5.997] | 0.0091 |
Platelet count (G/L) | ||||||
≥130 <130 | 4.023 | [1.512-10.703] | 0.0053 | NS | ||
Weight loss >10% | ||||||
No Yes | 2.633 | [1.079-6.423] | 0.0334 | NS | ||
Number of metastases | ||||||
≤2 >2 | 1.776 | [0.913-3.453] | 0.0904 | NS | ||
Number of chemotherapy lines | ||||||
≤1 >1 | 0.0305 | NS | ||||
Albumin (g/L) | ||||||
≥38 <38 | 1.585 | [0.722-3.481] | 0.2510 | - | ||
CRP (mg/L) | ||||||
≤10 >10 | 1.499 | [0.718-3.132] | 0.2812 | - | ||
Lymphocyte Count | ||||||
≥700/μL <700/μL | 1.297 | [0.684-2.462] | 0.4258 | - | ||
Liver metastases | ||||||
No Yes | 0.809 | [0.415-1.581] | 0.5359 | - | ||
Quality of life using 0-10 VAS | ||||||
≥5 <5 | 0.841 | [0.445-1.592] | 0.5953 | - | ||
Age (years) | ||||||
≤60 >60 | 0.919 | [0.495-1.710] | 0.7907 | - | ||
Previous adjuvant chemotherapy | ||||||
No Yes | 0.863 | [0.265-2.816] | 0.8074 | - | ||
LDH (U/L) ≤600 >600 | 1.079 | [0.501-2.326] | 0.8462 | - | ||
Absolute Neutrophil Count | ||||||
≥2 <2 | 1.190 | [0.161-8.801] | 0.8648 | - |