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Table 3 Prognostic parameters on univariate and multivariate analysis for lung cancer patients

From: Factors of interrupting chemotherapy in patients with Advanced Non-Small-Cell Lung Cancer

 

Univariate analysis

Multivariate analysis

 

HR

95% CI

p

HR

95% CI

p

ECOG Performance Status assessed by the physician

0-1

>1

3.641

[1.743-7.607]

0.0006

3.279

[1.546-6.955]

0.0020

Hemoglobin

Normal

Abnormal†

2.941

[1.401-6.172]

0.0044

2.781

[1.290-5.997]

0.0091

Platelet count (G/L)

≥130

<130

4.023

[1.512-10.703]

0.0053

  

NS

Weight loss >10%

No

Yes

2.633

[1.079-6.423]

0.0334

  

NS

Number of metastases

≤2

>2

1.776

[0.913-3.453]

0.0904

  

NS

Number of chemotherapy lines

≤1

>1

  

0.0305

  

NS

Albumin (g/L)

≥38

<38

1.585

[0.722-3.481]

0.2510

  

-

CRP (mg/L)

≤10

>10

1.499

[0.718-3.132]

0.2812

  

-

Lymphocyte Count

≥700/μL

<700/μL

1.297

[0.684-2.462]

0.4258

  

-

Liver metastases

No

Yes

0.809

[0.415-1.581]

0.5359

  

-

Quality of life using 0-10 VAS

≥5

<5

0.841

[0.445-1.592]

0.5953

  

-

Age (years)

≤60

>60

0.919

[0.495-1.710]

0.7907

  

-

Previous adjuvant chemotherapy

No

Yes

0.863

[0.265-2.816]

0.8074

  

-

LDH (U/L)

≤600

>600

1.079

[0.501-2.326]

0.8462

  

-

Absolute Neutrophil Count

≥2

<2

1.190

[0.161-8.801]

0.8648

  

-

  1. LDH: lactate dehydrogenase; CRP: C-reactive protein; VAS: visual analog scale. †<11.5 g/dL for female; <13.0 g/dL for male