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Figure 5 | BMC Research Notes

Figure 5

From: Allelic replacement of the streptococcal cysteine protease SpeB in a Δsrv mutant background restores biofilm formation

Figure 5

Hypothetical model of Srv/SpeB mediated GAS biofilm formation and dispersal. Following GAS exposure, Srv-mediated negative regulation of SpeB production would allow biofilm formation and colonization. As of yet unidentified environmental signals may reverse this control, promoting SpeB production and subsequent biofilm dispersal in order to facilitate dissemination/transmission of the organism. We hypothesize that this cycle is likely held in equilibrium such that controlled amounts of SpeB may be produced to allow dissemination without complete disruption of the GAS biofilm.

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