Figure 4

Detection of small aberrations in MYC and CDKN2A / CDKN2B loci. A: Array-CGH showed a high level of amplification. The amplified region of was about 700 kb in size involving the MYC locus on the long arm of chromosome 8. Arrows point out an enlargement of the MYC locus. B: Interphase FISH verification using chromosome 8 centromere specific probe (green) and MYC locus specific BAC probe (red) on the corresponding dFFPE section. The red arrow indicates signals of the amplified MYC locus and white arrow points to the normal locus. C: Array-CGH result of a case with homozygous deletion. The estimated size of the homozygous deleted area was about 600 kb involving the CDKN2A/CDKN2B loci on the short arm of chromosome 9. Arrows point out the region of the homozygous deletion, containing the CDKN2A/CDKN2B loci.