Figure 5

ClueGO analysis [57]of 64 genes upregulated during Rb-/- MEF adipocyte differentiation in comparison to Rb+/+ MEF adipocyte differentiation (sum of differences of log2-fold change > 4). Nodes (circles) represent gene ontology terms. Connections between two nodes (edges) indicate that two gene ontology terms share genes from the considered dataset (agreement measure kappa ≥ 0.3). The calculated kappa score is also used for defining functional groups, which are indicated by the same color. The most prominent gene ontology term for each group (theme) is highlighted: mitochondrion organization (red), electron transport (blue), triglyceride metabolic process (green), apoptosis (orange).