Figure 4

Canonical pathways most significantly regulated by E1A expression in quiescent cells. A: The stacked bar chart displays for each canonical pathway the number of genes that were found significantly up-regulated (red), and down-regulated (green) by Bayesian model selection. The molecules/genes in a given pathway that were not found in our list of significantly regulated genes are termed unchanged (grey) or not overlapping with our dataset (white). The numerical value at the top of each bar represents the total number of genes/molecules in the canonical pathway. The Benjamini-Hochberg (BH) method was used to adjust the right-tailed Fisher's Exact t-test p-values, which measure how significant each pathway is. B: The intensity of the node color (red) indicates the expression level or degree of up regulation, and those genes either in grey or without color were not found in our list of significantly regulated genes.