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Table 1 Sample Gene Ontology terms and GO Trimming results

From: GO Trimming: Systematically reducing redundancy in large Gene Ontology datasets

ID

GO Accession

GO Term

p-value

Diff. Genes

Total Genes

1

GO:0031532

actin cytoskeleton reorganization

0.00338

5

12

2

GO:0009620

response to fungus

3.04E-09

10

12

3

GO:0006037

cell wall chitin metabolic process

3.04E-09

10

12

3

GO:0044036

cell wall macromolecule metabolic process

3.04E-09

10

12

3

GO:0010383

cell wall polysaccharide metabolic process

3.04E-09

10

12

4

GO:0003796

lysozyme activity

3.04E-09

10

12

 

GO:0001101

response to acid

3.04E-09

10

12

5

GO:0046578

regulation of Ras protein signal transduction

6.77E-04

6

13

5

GO:0051056

regulation of small GTPase mediated signal transduction

6.77E-04

6

13

6

GO:0008061

chitin binding

1.21E-08

10

13

7

GO:0006032

chitin catabolic process

1.21E-08

10

13

3

GO:0006030

chitin metabolic process

1.21E-08

10

13

8

GO:0004568

chitinase activity

1.21E-08

10

13

9

GO:0003746

translation elongation factor activity

0.00727

5

14

3

GO:0071554

cell wall organization or biogenesis

3.86E-08

10

14

 

GO:0008643

carbohydrate transport

0.0226

5

18

10

GO:0005885

Arp2/3 protein complex

0.0226

5

18

9

GO:0006414

translational elongation

0.00485

6

18

11

GO:0045165

cell fate commitment

0.0284

5

19

 

GO:0035091

phosphoinositide binding

0.00652

6

19

7

GO:0006026

aminoglycan catabolic process

2.29E-06

10

19

12

GO:0030126

COPI vesicle coat

0.0140

6

22

12

GO:0030663

COPI coated vesicle membrane

0.0140

6

22

7

GO:0000272

polysaccharide catabolic process

1.36E-06

11

22

13

GO:0003007

heart morphogenesis

0.0175

6

23

12

GO:0030660

Golgi-associated vesicle membrane

0.0215

6

24

12

GO:0030137

COPI-coated vesicle

0.0215

6

24

14

GO:0005859

muscle myosin complex

0.0215

6

24

14

GO:0016460

myosin II complex

0.0215

6

24

15

GO:0001725

stress fiber

0.00546

7

24

15

GO:0032432

actin filament bundle

0.00546

7

24

15

GO:0042641

actomyosin

0.00697

7

25

3, 7

GO:0006022

aminoglycan metabolic process

1.04E-05

11

26

16

GO:0030239

myofibril assembly

0.0134

7

28

16

GO:0031032

actomyosin structure organization

0.00441

8

29

17

GO:0016363

nuclear matrix

0.00134

9

30

17

GO:0034399

nuclear periphery

0.00174

9

31

18

GO:0007586

digestion

4.24E-06

13

33

19

GO:0001726

ruffle

0.0146

8

35

20

GO:0005529

sugar binding

6.58E-06

14

39

3, 7

GO:0005976

polysaccharide metabolic process

2.20E-04

12

40

 

GO:0005938

cell cortex

0.0407

8

42

16

GO:0010927

cellular component assembly involved in morphogenesis

0.0174

9

43

21

GO:0022627

cytosolic small ribosomal subunit

1.20E-05

15

46

22

GO:0004322

ferroxidase activity

4.18E-07

17

46

22

GO:0016724

oxidoreductase activity, oxidizing metal ions, oxygen as acceptor

4.18E-07

17

46

6

GO:0030247

polysaccharide binding

7.26E-05

14

47

6

GO:0001871

pattern binding

7.26E-05

14

47

22

GO:0016722

oxidoreductase activity, oxidizing metal ions

1.18E-06

17

49

23

GO:0022625

cytosolic large ribosomal subunit

0.0428

9

50

7

GO:0016052

carbohydrate catabolic process

6.10E-05

15

52

4, 8

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

5.05E-05

16

57

21

GO:0015935

small ribosomal subunit

1.58E-05

17

58

24

GO:0005200

structural constituent of cytoskeleton

0.0210

11

59

23

GO:0015934

large ribosomal subunit

0.0328

11

63

19

GO:0031252

cell leading edge

0.0364

11

64

4, 8

GO:0016798

hydrolase activity, acting on glycosyl bonds

2.74E-04

16

65

6, 20

GO:0030246

carbohydrate binding

1.64E-04

18

75

2

GO:0051707

response to other organism

0.00451

15

76

21, 23

GO:0022626

cytosolic ribosome

9.78E-06

24

98

25

GO:0016791

phosphatase activity

0.0314

17

111

16

GO:0032989

cellular component morphogenesis

0.0160

18

111

25

GO:0016311

dephosphorylation

0.0365

17

113

26

GO:0003735

structural constituent of ribosome

3.52E-06

28

118

21, 23

GO:0033279

ribosomal subunit

5.92E-06

28

121

1, 16

GO:0030036

actin cytoskeleton organization

0.00597

21

124

21, 23

GO:0044445

cytosolic part

3.27E-05

27

125

7

GO:0009057

macromolecule catabolic process

0.0131

21

133

25

GO:0042578

phosphoric ester hydrolase activity

0.0457

20

142

 

GO:0006955

immune response

0.0486

20

143

1, 16

GO:0030029

actin filament-based process

0.0189

22

146

27

GO:0005615

extracellular space

0.00507

24

146

21, 23

GO:0005840

ribosome

8.61E-05

29

146

19

GO:0042995

cell projection

0.00775

24

151

10, 14, 15

GO:0015629

actin cytoskeleton

0.0282

24

169

1, 16

GO:0007010

cytoskeleton organization

0.0115

29

198

3, 7

GO:0005975

carbohydrate metabolic process

0.0121

31

216

9

GO:0006412

translation

4.07E-04

38

229

27

GO:0044421

extracellular region part

0.0135

33

235

21, 23

GO:0030529

ribonucleoprotein complex

0.00101

43

281

24, 26

GO:0005198

structural molecule activity

2.31E-05

53

316

21, 23

GO:0005829

cytosol

0.00275

47

330

27

GO:0005576

extracellular region

0.00841

46

341

9

GO:0003723

RNA binding

5.39E-04

53

356

9

GO:0003676

nucleic acid binding

0.00866

73

588

13, 28

GO:0007275

multicellular organismal development

0.0203

89

764

10, 14, 15, 21, 23

GO:0043232

intracellular non-membrane-bounded organelle

0.0186

95

819

10, 14, 15, 21, 23

GO:0043228

non-membrane-bounded organelle

0.0186

95

819

11, 13, 16, 28

GO:0032502

developmental process

0.0307

105

934

18, 28

GO:0032501

multicellular organismal process

0.0273

119

1067

  1. List of experimentally-derived Gene Ontology terms significantly enriched (p-value ≤ 0.05; no MTC) by the differential gene list. Columns show identifiers for hierarchical connections, GO accession numbers, GO term descriptors, enrichment p-values, numbers of genes in differentially regulated gene list annotated with GO term, and total numbers of genes on microarray annotated with GO term. Terms in plain text are retained after GO Trimming with all uniqueness threshold values. Bolded terms are removed with a 0% threshold. Bolded and italicized terms are additionally removed when 40% is used as uniqueness threshold for GO Trimming, and bolded, italicized and underlined terms are additionally removed with a 50% threshold.