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Table 2 Important histopathological findings of tissues obtained at autopsy and specific clinical data

From: Histopathological diagnosis of myocarditis in a dengue outbreak in Sri Lanka, 2009

Age (y)
Gender
Major clinical manifestations Histological findings
16,F Effusions
Hypotension
Tachycardia
ECG- T ↓ Troponin T +
2D echo +
Heart - Interstitial oedema, infiltration of acute inflammatory cells, necrosis of myocardial fibers (appearance of myocarditis).
Lungs - capillary congestion, alveoli filled with histiocytes and fibrinous debris (appearance of diffuse alveolar damage).
28,M Effusions
Hypotension
Tachycardia
Spontaneous bleeding
ECG- T ↓ Troponin T +
2D echo +
Heart - interstitial oedema, haemorrhage with scattered inflammatory cells and necrotic myocardial fibers, infiltration of pericardium by acute inflammatory cells (appearance of myocarditis and pericarditis).
Lungs - extensive pulmonary oedema and haemorrhage.
Brain - vascular congestion with cerebral oedema.
Skeletal muscle - haemorrhage in perimycium.
28,M Effusions
Hypotension
Tachycardia
ECG- T ↓ Troponin T +
Heart - interstitial oedema, inflammation and necrotic muscle fibers (appearance of myocarditis).
Lungs - septal congestion and haemorrhage with pulmonary oedema.
Brain - meningeal congestion.
Spleen - widened red pulp and haemorrhage.
31,F Effusions
Hypotension
Tachycardia
ECG- T ↓ Troponin T +
2D echo +
Heart - interstitial oedema, scattered necrosis of myocardial fibers surrounded predominantly by lymphocytes (appearance of myocarditis).
Lungs - extensive neutrophilic exudates in alveoli with capillary congestion (appearance of severe pneumonia leading to acute respiratory distress syndrome).
Liver - massive necrosis.
13,F Effusions
Hypotension
Tachycardia Bleeding ECG- T ↓
Troponin T +
Heart - interstitial oedema and scattered necrosis of myocardial fibers surrounded predominantly by lymphocytes (appearance of myocarditis).
Liver - Macrovesicular steatosis.