Table 2 Important histopathological findings of tissues obtained at autopsy and specific clinical data
From: Histopathological diagnosis of myocarditis in a dengue outbreak in Sri Lanka, 2009
Age (y) Gender | Major clinical manifestations | Histological findings |
|---|---|---|
16,F | Effusions Hypotension Tachycardia ECG- T ↓ Troponin T + 2D echo + | Heart - Interstitial oedema, infiltration of acute inflammatory cells, necrosis of myocardial fibers (appearance of myocarditis). Lungs - capillary congestion, alveoli filled with histiocytes and fibrinous debris (appearance of diffuse alveolar damage). |
28,M | Effusions Hypotension Tachycardia Spontaneous bleeding ECG- T ↓ Troponin T + 2D echo + | Heart - interstitial oedema, haemorrhage with scattered inflammatory cells and necrotic myocardial fibers, infiltration of pericardium by acute inflammatory cells (appearance of myocarditis and pericarditis). Lungs - extensive pulmonary oedema and haemorrhage. Brain - vascular congestion with cerebral oedema. Skeletal muscle - haemorrhage in perimycium. |
28,M | Effusions Hypotension Tachycardia ECG- T ↓ Troponin T + | Heart - interstitial oedema, inflammation and necrotic muscle fibers (appearance of myocarditis). Lungs - septal congestion and haemorrhage with pulmonary oedema. Brain - meningeal congestion. Spleen - widened red pulp and haemorrhage. |
31,F | Effusions Hypotension Tachycardia ECG- T ↓ Troponin T + 2D echo + | Heart - interstitial oedema, scattered necrosis of myocardial fibers surrounded predominantly by lymphocytes (appearance of myocarditis). Lungs - extensive neutrophilic exudates in alveoli with capillary congestion (appearance of severe pneumonia leading to acute respiratory distress syndrome). Liver - massive necrosis. |
13,F | Effusions Hypotension Tachycardia Bleeding ECG- T ↓ Troponin T + | Heart - interstitial oedema and scattered necrosis of myocardial fibers surrounded predominantly by lymphocytes (appearance of myocarditis). Liver - Macrovesicular steatosis. |