Figure 3

Predicted active sites extending to enzyme surface of CYP6AA3 (A), CYP6P7 (B), and CYP6P8 (C). Active sites were calculated using VOIDOO. I-helices of CYP6AA3 (gold), CYP6P7 (silver), and CYP6P8 (magenta) are depicted in cartoon, spanning across heme. Caption in each figure corresponds to molecular surface view of each access channel. CYP6AA3 and CYP6P7 both display an oval shape of access opening, while CYP6P8 has a relatively small circular pore. The R114 guanidino group is shown projected horizontally to the opening of the CYP6P8 channel. Carbon atoms in caption are colored separately on each structure, oxygen and nitrogen atoms are shown in red and blue, respectively. The heme group in the middle of the structure is represented by red stick.