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Figure 4 | BMC Research Notes

Figure 4

From: Homology modeling of mosquito cytochrome P450 enzymes involved in pyrethroid metabolism: insights into differences in substrate selectivity

Figure 4

Deltamethrin binding modes in active sites of CYP6AA3 (A-D) and CYP6P7 (E). CYP6AA3 exhibited 4 binding modes of deltamethrin positioning close to heme iron: geminal-dimethyl group (A), 5-phenoxybenzyl carbon (B), 4/-phenoxybenzyl carbon (C), and cyano group (D). Single binding mode of deltamethrin in CYP6P7 was obtained with 4/-phenoxybenzyl carbon as a predicted hydroxylation site (E). Same color is applied for heme and all elements as in Figure 3.

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