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Figure 1 | BMC Research Notes

Figure 1

From: Genetic screening of Fabry patients with EcoTILLING and HRM technology

Figure 1

Diagram of sample pooling - (A) For the pooling strategy, 64 samples were first allocated in an 8 × 8 grid and then mixed in pools of 8 samples each. (B) The 16 pools obtained were arranged in a second plate and subjected to the EcoTILLING protocol. After enzymatic digestion, the identification of the pools with the same fragments permits the identification of the presence of heterozygotes and to go back to the coordinates that identify the mutated sample.

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