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Table 1 Top 30 orphan proteins for further study

From: Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor

Gene Name

Annotation

Final rank

Orphanicity rank

Exp. quantile

p-value

act

bac

non-bac

SCO1521

hypothetical protein

1

1

0.21

3.71E-10

44

5

5

SCO2301

hypothetical protein

6

4

0.34

3.27E-07

43

5

5

SCO5362

hypothetical protein

6.5

9

0.13

2.02E-07

44

4

7

SCO1769

hypothetical protein

8

5

0.12

3.08E-08

40

3

1

SCO5746

hypothetical protein

8

7

0.18

4.38E-18

20

3

1

SCO3882

hypothetical protein

8.5

2

0.18

6.71E-08

38

5

1

SCO5546

hypothetical protein

8.5

14

0.35

7.62E-09

42

3

6

SCO5745

hypothetical protein

9.5

17

0.02

9.49E-10

43

4

6

SCO1925

hypothetical protein

11.5

18

0.09

1.24E-07

44

5

3

SCO2577

hypothetical protein

12

3

0.64

2.66E-07

41

5

1

SCO1676

hypothetical protein

12.5

15

0.32

7.05E-09

31

1

4

SCO1919

hypothetical protein

12.5

11

0.16

5.74E-07

44

4

2

SCO5491

hypothetical protein

12.5

6

0.35

3.07E-07

32

3

3

SCO2081

hypothetical protein

13

8

0.60

2.88E-08

38

2

1

SCO2902

hypothetical protein

14.5

22

0.37

3.05E-07

43

5

4

SCO1522

hypothetical protein

15.5

19

0.19

6.47E-07

43

3

5

SCO1920

hypothetical protein

16

12

0.27

1.71E-06

42

5

5

SCO3839

hypothetical protein

16.5

27

0.35

1.60E-08

35

3

2

SCO3960

hypothetical protein

17.5

13

0.30

5.66E-08

29

5

1

SCO2901

hypothetical protein

18

23

0.36

5.37E-07

41

3

5

SCO1924

hypothetical protein

18.5

20

0.08

6.81E-08

44

1

2

SCO6766

hypothetical protein

18.5

10

0.19

4.55E-08

20

1

2

SCO1775

hypothetical protein

21

16

0.32

3.00E-06

42

4

2

SCO1222

hypothetical protein

22

21

0.43

3.33E-09

27

1

1

SCO5645

hypothetical protein

22

28

0.07

3.11E-07

36

4

2

SCO1530

hypothetical protein

24.5

24

0.03

8.99E-07

43

1

5

SCO2497

hypothetical protein

26.5

29

0.52

2.38E-06

37

5

7

SCO5787

hypothetical protein

27

26

0.12

5.88E-06

44

3

7

SCO2599

hypothetical protein

27.5

25

0.13

4.17E-07

44

1

1

SCO5711

hypothetical protein

29.5

30

0.12

8.65E-06

44

5

5

  1. The proteins are prioritized according to their conservation across actinomycetes, bacteria and non-bacteria; their expression dynamics (summarized in the p-value); and their orphanicity, i.e. the absence of any functional information, assessed as described in the text.