Haplotype analysis of the 5,10-methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (E429A) polymorphism

Table 3 Haplotypes of A- and C-alleles of MTHFR c.1298A>C.

HT	c.129C>T	IVS2 533 G>A	c.677C>T	c.1068C>T	IVS10 262C>G	1298A	1298C
1	C	G	C	C	C	0.3201	0.1043
2	C	G	T	C	C	0.2956	0
3	C	G	T	C	G	0.1113	0
4	C	G	C	C	G	0.1026	0.2287
5	C	A	T	C	C	0.0661	0
6	C	A	C	C	G	0.0432	0.3468
7	C	A	T	C	G	0.0384	0
8	T	A	C	C	C	0.0114	0.1279
9	C	G	C	T	C	0.0114	0.1128
10	T	G	C	T	C	0	0.0390
11	T	A	C	T	C	0	0.0160
12	T	G	C	T	C	0	0.0122
13	C	G	T	T	C	0	0.0122

Haplotypes with an estimated frequency below 0.01 are not shown. Numbering refers to haplotypes of c.1298A alleles (1-13; the additional c.1298 haplotypes not observed in c.1298A (C) alleles were numbered consecutively regarding their frequency). Frequencies are shown as the ratio of total amount of each 1298A and 1298C-alleles.