From: Computational analysis of expression of human embryonic stem cell-associated signatures in tumors
Group | Gene set | #Genes | Description |
---|---|---|---|
 | hESC exp1 | 379 | Overexpressed in hESCs according to 5 or more out of 20 profiling studies |
 | hESC exp2 | 40 | Overexpressed in hESCs according to a meta-analysis of 8 profiling studies |
 | hESC exp3 | 48 | Overexpressed in hESCs in at least 10 studies |
 | hESC exp4 | 30 | Underexpressed in hESCs in at least 6 studies |
 | hESC exp5 | 189 | TF genes in hESCs |
hESC expressed | hESC exp6 | 44 | Highly expressed in undifferentiated hESCs |
 | hESC exp7 | 994 | High connectivity (≥ 500) in the global co-expression networks of hESCs |
 | hESC exp8 | 22 | Candidate hESC markers |
 | hESC exp9 | 27 | Differentially upregulated in hESCs |
 | hESC exp10 | 31 | The most abundant transcripts expressed in hESCs |
 | hESC exp11 | 1, 000 | Significantly identified in hESC lines by SAM analysis |
 | Nanog targets | 988 | Genes activated by Nanog in hESCs |
 | Oct4 targets | 290 | Genes activated by Oct4 in hESCs |
NOS targets | Sox2 targets | 734 | Genes activated by Sox2 in hESCs |
 | NOS targets | 179 | Overlap of three above sets |
 | NOS TFs | 37 | Transcription regulators in NOS targets set |
 | NOS co-bound | 353 | Genes co-bound by Nanog, Oct4 and Sox2 in hESCs |
 | Suz12 targets | 1, 040 | Genes bound by Suz12 |
Polycomb targets | Eed targets | 1, 066 | Genes bound by Eed |
 | H3K27 bound | 1, 121 | Genes bound by H3K27 |
 | PRC2 targets | 654 | Overlap of three above sets |
Myc targets | Myc targets1 | 230 | E-box-containing genes regulated by c-Myc in cultured cell lines |
 | Myc targets2 | 775 | Genes commonly regulated by c-Myc and Max in a Burkitt's lymphoma cell line |
P53 targets | Â | 35 | Common gene lists regulated by p53 in mouse and human |