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Table 2 Results of 20 patients with cancer of unknown primary tumors.

From: Detection of primary sites in unknown primary tumors using FDG-PET or FDG-PET/CT

Patient no.

Sex

Age

Site of metastases

Pathology

PET or

PET/CT

PET or PET/CT finding

Primary site

detected by IHC

IHC markers

used to detect primary site

      

Primary tumor

Known metastases

Additional findings

Results of

additional findings

  

1

M

54

Cervical LN

Squamous cell ca.

PET

not seen

seen

-

-

-

-

2

F

66

Bone

PD

PET/CT

not seen

seen

-

-

-

Vimentin, CK 7,

CK 20, CD 68

3

M

55

Cervical LN

PD

PET→PET/CT

not seen

seen

-

-

-

CK 7, CK 19, CK 20, Thyroglobulin,

4

F

57

Bone

Signet ring cell ca.

PET/CT

not seen

seen

Neck, thyroid, hand, forearm uptake

Benign

-

CK 7, CK 20, TTF-1,

ER, PR

5

M

56

Skin

Adenocarcinoma

PET→PET/CT

not seen

not seen

Mid-esophagus uptake (subcarinal LN)

Benign

-

CK 7, CK 19, CK 20

TTF-1

6

F

36

Bone

Adenocarcinoma

PET

not seen

seen

-

-

Breast

ER, PR, C-erbB2,

CK 7, CK 20, TTF-1, GCDFP-15

7

F

62

Abdominal LN

PD

PET/CT

not seen

seen

Pharynx, thyroid, uptake

Benign

-

-

8

M

15

Cervical LN

PD

PET

not seen

seen

-

-

-

CK, Vimentin, CD 68

9

M

54

Cervical LN

Squamous cell ca.

PET/CT

not seen

seen

-

-

-

-

10

M

46

Brain

Leiomyosarcoma

PET→PET/CT

not seen

seen

Left lower lung uptake

Benign

-

CD 34, Smooth muscle actin, CD 68

11

F

34

Cervical LN

PD

PET

not seen

seen

-

-

Lung

CK 7, CK 20, TTF-1

12

F

60

Omentum

Adenocarcinoma

PET/CT

not seen

*

*

*

-

CK7, CK 20

13

F

48

Peritoneum

Adenocarcinoma

PET/CT

not seen

seen

Inguinal LN uptake

Malignant

-

CK7, CK 20

14

F

60

Axillary LN

PD

PET

not seen

seen

-

-

-

CK 7, CK 20, TTF-1

15

M

61

Cervical LN

PD

PET→PET/CT

not seen

seen

-

-

-

CK, leukocyte common antigen

16

F

53

Ureter

PD

PET/CT

not seen

*

*

*

-

CK 7, CK 20

17

M

59

Abdominal LN

Adenocarcinoma

PET/CT

not seen

seen

Thyroid uptake

Benign

-

CK 7, CK 19, CK 20, TTF-1

18

M

68

Abdominal LN

PD

PET

not seen

*

*

*

-

CD 56, CK

19

F

51

Axillary LN

PD

PET/CT

not seen

seen

-

-

-

CK 7, CK 20, TTF-1

20

F

43

Bone

PD

PET

not seen

seen

Neck LN uptake

Malignant

-

CK 7, CK 20

  1. *PET or PET/CT was done several months later at the time of the initial workup.
  2. Abbreviation: LN = lymph node., ca. = carcinoma, PD = poorly differentiated carcinoma, CT = computed tomography, PET = positron-emission tomography, IHC = immunohistochemistry, ER = estrogen- receptor, PR = progesterone- receptor, CK = cytokeratin, TTF-1 = thyroid transcription factor-1, GCDFP-15 = gross cystic disease