- Short Report
- Open Access
Acceptance and Adverse Effects of H1N1 Vaccinations Among a Cohort of National Guard Health Care Workers during the 2009 Hajj Season
© Balkhy et al; licensee BioMed Central Ltd. 2011
Received: 27 April 2010
Accepted: 13 March 2011
Published: 13 March 2011
The H1N1 influenza pandemic had garnered a large amount of attention. Currently, the most effective preventive measure available is the H1N1 vaccine. We aimed to assess the willingness of our study participants to receive the H1N1 vaccination prior to the annual Hajj season. If any participant declined, we investigated the reasons for vaccine rejection.
We conducted a prospective cohort study of National Guard employees during the 1430 (2009) Hajj season. A survey was used as the primary method for data collection. Participants were vaccinated one to two weeks prior to their trip to Mona, and any side effects reported at the time of injection and three weeks post vaccination were recorded.
There were 100 male and 26 female participants in the study. In total, 66.7% (n = 84) of the participants were health care workers (HCWs) and 33.3% (n = 42) were non-health care workers (non-HCWs). Less than half of the respondents (46.8%, n = 59) accepted the vaccination. The vaccination acceptance rate was higher among non-HCWs, at a rate of 71.4% (n = 30); HCWs only accepted at a rate of 34.5% (n = 29) (OR 1.103, 95% CI [0.488-2.496]). The most common reason for vaccine refusal was the impression that the disease was not fatal (25.4%, n = 32). Finally, all participants reported pain at the injection site and 18.3% (n = 11) reported swelling. All other side effects were reported in less than 15% of the participants.
Despite fears of the new H1N1 vaccine, there was a reasonable rate of vaccine acceptance among our study participants. Early health education may increase the rate of acceptance of the H1N1 vaccine. Furthermore, additional research is needed on long-term adverse effects of the H1N1 vaccine.
The Hajj is an annual Muslim pilgrimage that begins on the first day of Dul-Hajja (12th lunar month) and continues for 13 days. The Hajj occurs at the holy city of Mecca in the Kingdom of Saudi Arabia (KSA). The two- to three-million people who gather in the small, confined holy sites of the city come from multiethnic Muslim communities around the world [1–3].
The Saudi National Guard is a military and security force that includes several sub-administrations, of which one is the National Guard Health Affairs. This group is charged with providing health care services to National Guard personnel and their dependents. The group also offers medical services as necessary during the Hajj and other similar situations involving large groups of people.
Influenza pandemics are significant health threats that have occurred periodically over the past 300 years . The most severe influenza pandemic, occurring from 1918 to 1919, killed approximately 30 to 50 million people worldwide. The emergence of the H5N1 avian influenza in 1997 promoted the recognition of the threat of another severe pandemic as a significant possibility, and such a pandemic would certainly be a threat at large gatherings such as the annual Hajj . In response to this emerging threat, large-scale mitigation strategies have been developed. One cornerstone of these efforts is mass vaccination . The current H1N1 pandemic, which was first recognized and defined in Mexico City in February 2009, spread rapidly throughout the world. Before the current Hajj season of 2009, the WHO declared there have been more than 300,000 laboratory confirmed cases of pandemic influenza H1N1 and 3,917 deaths in 191 countries .
In the current study, we assessed the acceptance of the H1N1 vaccination. We also examined possible barriers to vaccination within this high-risk cohort of employees, including both HCWs and non-HCWs, who worked at one of the largest human gatherings in the world.
Materials and methods
We conducted our study in Jeddah, the second-largest city in the KSA, where the National Guard medical and security teams were assigned to serve during the past Hajj season. Participants were recruited from the King Khalid National Guard Hospital, where the administration had assigned 150 HCWs and 350 non-HCWs for both health care and security services. This total number of employees was considered to be the baseline population for our study sample recruitment.
The study was designed as a prospective cohort study. Participants were interviewed by the primary investigator after verbal consent was obtained. The first section of the interview included the collection of the following information: demographic characteristics, interest in vaccination, and reasons for refusing vaccination (if applicable). The second section of the interview focused on any experienced side effects (if applicable). The interview was conducted with all the employees staffed at the vaccination clinic two weeks prior to the beginning of the Hajj. After consenting to participate in the study, respondents were assessed for baseline measures, as well as signs and symptoms of the flu. After the assessment, willing participants were vaccinated. The cohort was followed during the Hajj for seven days and assessed one week after the end of the Hajj, a time when all employees had returned to their jobs in Jeddah City.
The sample size was estimated based on results from a previous study showing that 5% of participants declined the H1N1 vaccine . Therefore, to determine an appropriate sample size for this study, we assumed that 10% of our population would refuse the vaccine. With a 5% margin for error and a power of 80%, these assumptions resulted in a necessary sample size of 199 participants. However, due to several logistic constraints, including delays in shipping by the manufacturing companies, only 126 participants (64% of the target sample size) were recruited.
Selection of participants
All National Guard HCWs and non-HCWs assigned to serve during the Hajj season in the National Guard campus clinics were expected to visit the staff clinic to complete paperwork. Participants were recruited for the study two weeks prior to their travel to Mecca, and those who gave consent were interviewed. Inclusion criteria included being a National Guard employee and being assigned to serve during the 2009 Hajj season. Those with positive results on an H1N1 PCR-based assay during the current influenza season were excluded from the study.
The questionnaire was written in English, translated into Arabic, and back-translated into English. It was reviewed by an experienced bilingual medical research staff member for content validity. Both forms were reviewed and approved by the Institutional Review Board of the King Abdullah International Medical Research Center (IRB of KAIMRC). The questionnaire contained 30 questions that focused on identifying information and socio-demographic characteristics. Those who accepted the vaccine were followed-up and questioned about immediate side effects. Those who refused the vaccine were questioned about their reasons for declining and about the most effective preventive measures they would apply in place of vaccination.
Interviews and data collection
All interviews were conducted during the employees' visit to the staff clinic, which was two weeks prior to arriving at Mecca. The follow-up lasted for a one-week period that followed the employees' work during the Hajj. A final follow-up visit for each participant occurred no less than ten days after the end of the Hajj. All questions were administered by a single interviewer to reduce possible bias. Each interview lasted for ten minutes, and the interviewer reviewed the questions for completeness after the end of each interview.
The Pandemrix H1N1 vaccine was administered during the study. Each 0.5-ml vaccine was injected intramuscularly into the upper arm. This medication is a split inactivated influenza virus vaccine containing antigen equivalent to the A/California/7/2009(H1N1)v-like strain (X-179A). Each 0.5-ml dose contained 3.75 μg of egg-propagated hemagglutinin-containing immunologic adjuvant .
Statistical data analysis
Data entry was performed using Microsoft Excel. After entry, the data were transferred to SPSS version 17 software for detailed descriptive analysis. The means and standard deviations of age were calculated.
Demographic characteristics of study participants
A total of 126 of 500 assigned employees were recruited for the study (25.2%). Of the total study participants, 100 (79.4%) were male and 26 (20.6%) female, with a mean age of 38.7 and standard deviation of 9.8 years. The majority of participants (n = 67, 53.2%) refused the H1N1 vaccination and preferred using other protective measures. The participants who were non-HCWs had a vaccine acceptance rate of 71.4%, whereas HCWs had a vaccine acceptance rate of 34.5% (OR of 1.103, 95% CI [0.488-2.496]).
Vaccine acceptance and preventive measures for disease transmission
Sociodemographic characteristics of National Guard employees assigned to serve during the 2009 Hajj season and reasons for refusing the H1N1 vaccination.
Reasons for refusal
n = 100
n = 26
n = 42
n = 84
No adequate safety studies
Contains toxic preservatives
Different from western vaccine
Misleading media information
Swine flu not a fatal disease
This is not an environment for H1N1
Frequent hand washing
Wearing a mask
Adverse vaccine events
Common adverse effects of H1N1 vaccination among National Guard employees assigned to serve during the 2009 Hajj season.
Total Number (%)
Male Number (%)
Female Number (%)
Pain at injection site
Swelling at injection site
In 2009, the large gathering of the annual pilgrimage (known as the Hajj) occurred concomitantly with the swine flu pandemic and the global panic surrounding the possibility of a rapid outbreak. For these reasons, we were interested in studying high-risk participants who were assigned to provide services during the pilgrimage. This allowed us to gather information about their attitudes toward the H1N1 vaccine. We were also interested in identifying and assessing the short-term adverse effects of the newly manufactured vaccine . Regarding the current pandemic, the WHO had recommended that all countries give high priority to immunizing their HCWs to protect the essential health infrastructure. Despite these recommendations, the acceptance of voluntary vaccination was unexpectedly low .
This study explored reasons for swine flu vaccination refusal during a time of global public concern and anticipation of a global outbreak. In our cohort of Saudi National Guard employees assigned to work during the Hajj, 46.8% of participants accepted the vaccination. We found that more non-HCWs (mainly military personnel) accepted the vaccine than HCWs. This was consistent with our previously published finding that physicians had a low acceptance rate for both seasonal and pandemic vaccinations in early 2009/2010 .
Despite strong recommendations to vaccinate healthcare workers with the influenza vaccine, coverage was exceedingly low for all specialties, with some differences according to location and type of employment . In addition to education about preventive measures, such as frequent hand washing and wearing a mask, vaccination is an essential protective measure. Influenza vaccination among healthy working adults has been shown to be highly effective, resulting in a 25% reduction of upper respiratory illness . In this study, the reasons for refusal included worries about vaccination safety and doubts about vaccine efficacy. In a study from Hong Kong, the influenza vaccine was efficient in preventing H1N1 infection in 61% of the participants . In addition, some participants believed that other preventive measures could be applied to yield the same benefits; misleading information from the media may have been the source of this reasoning. One of the prominent sources of concern was the difference in chemical constituents between the vaccine used in developed countries and those used in developing countries including the Kingdom. Participants' hesitance, worry, and safety concerns about using a newly developed vaccine were other major determinants of negative response and vaccination refusal. The most common reasons for accepting the vaccination were a "wish to be protected" and "following health authority advice." The most common reason for refusal was "worry about side effects." In addition, some other reasons for refusing vaccination included "doubts about the efficacy of the vaccine," feeling that it was "not yet the right time to be vaccinated," and "simply not wanting the vaccine ." Vaccine-seeking consumers must first be convinced of a reasonable likelihood that the disease will occur in their location and that they are susceptible. Additionally, they must be convinced that the disease is serious. Finally, they must be convinced of the safety, if not the efficacy, of the vaccine before they will accept it . In a recent study conducted on a group of Saudi civilians, we were able to confirm that the media played a major role in decreasing the acceptance of the vaccine. Furthermore, the lack of public education by knowledgeable HCWs may have also contributed to popular belief in the negative propaganda . Campaigns and health education in advance to the next anticipated influenza outbreaks could play an essential role in encouraging communities to accept vaccinations during similar future circumstances.
Side effects experienced by the vaccinated individuals in the cohort consisted of normal short-term adverse effects . Therefore, the vaccine is promising for future use if any outbreak is expected, assuming that further assessment of the long-term adverse effects yields positive results.
Based on surveillance following the 1976 swine flu vaccination program, the risk of anaphylaxis from the influenza vaccination was estimated to be approximately one in every four million people. In 1976, Guillain-Barré syndrome was associated with receipt of the swine flu vaccine, with a risk of 1 per 100,000 individuals vaccinated . Safety and efficacy are critical factors in determining the rate of vaccination in the general population. Governments that want to promote H1N1 vaccination will need to gain a better understanding of the barriers to and facilitators of acceptability before implementing full-scale vaccination programs .
The current study demonstrated a substantial increase in participant awareness. Most participants understood that applying as many protective measures as possible allows for the best protection from swine flu infection. Our results also suggest that frequent hand washing is seen as one of the most influential protective measure. When participants were asked about future vaccines three weeks after the vaccination campaign, an increased number of participants (11 out of 67) had changed their minds and would accept vaccination in the future. This change of opinion among the participants could contribute to a higher acceptance rate if vaccinations are offered during future pandemics. The presence of participants in the same campus for three weeks post-vaccination, coupled with an exchange of information between the accepting and refusing groups, may have been the reasons that some participants changed their willingness to receive a future vaccination. HCWs were seriously deficient in terms of their knowledge of influenza prevention. Extensive and sustained efforts to overcome these limitations are urgently needed among HCWs, regardless of whether they are involved in direct or indirect patient care . These efforts will help to increase effective compliance among HCWs and the general public.
Several limitations of this study were considered and acknowledged by our research team. First, the inclusion of a specific cohort of National Guard employees limits the wider generalizability and application of the research findings, as these employees are mainly from the local area and have extensive experience with the Hajj. Therefore, our cohort may not feel threatened by participation in such an international mass gathering. Second, the small sample size of participants may have hindered the ability to detect statistical significance; this may have resulted in a type II error (i.e., the sample size was not sufficiently large to confirm a difference between the groups).
In the context of global panic surrounding H1N1 and the possibility of an outbreak in a large gathering such as the Hajj, this study found that the acceptance rate for mass vaccination was low among HCWs but acceptable among non-HCWs. Further, our study recognized and characterized major barriers preventing H1N1 vaccination acceptance. Another significant finding of our analysis was the report of mild (within the normal range) short-term adverse effects experienced by our cohort.
The authors would like to thank the King Abdullah International Medical Research Center and King Saud bin Abdulaziz University for Health Sciences for supporting the research described in this manuscript.
- Balkhy HH, Memish ZA, Bafaqeer S, Almuneef MA: Influenza a common viral infection among Hajj pilgrims: time for routine surveillance and vaccination. J Travel Med. 2004, 11 (2): 82-86. 10.2310/7060.2004.17027.PubMedView ArticleGoogle Scholar
- Memish ZA, Ahmed QA: Mecca bound: the challenges ahead. J Travel Med. 2002, 9 (4): 202-210. 10.2310/7060.2002.24557.PubMedView ArticleGoogle Scholar
- Qureshi H, Gessner BD, Leboulleux D, Hasan H, Alam SE, Moulton LH: The incidence of vaccine preventable influenza-like illness and medication use among Pakistani pilgrims to the Haj in Saudi Arabia. Vaccine. 2000, 18 (26): 2956-2962. 10.1016/S0264-410X(00)00116-X.PubMedView ArticleGoogle Scholar
- El-Sheikh SM, El-Assouli SM, Mohammed KA, Albar M: Bacteria and viruses that cause respiratory tract infections during the pilgrimage (Haj) season in Makkah, Saudi Arabia. Trop Med Int Health. 1998, 3 (3): 205-209.PubMedGoogle Scholar
- Potter CW: A history of influenza. J Appl Microbiol. 2001, 91 (4): 572-579. 10.1046/j.1365-2672.2001.01492.x.PubMedView ArticleGoogle Scholar
- Beigi RH, Switzer GE, Meyn LA: Acceptance of a pandemic avian influenza vaccine in pregnancy. J Reprod Med. 2009, 54 (6): 341-346.PubMedGoogle Scholar
- World Health Organization. Global Alert and Response. Pandemic H1N1 (2009) update- 67. [http://www.who.int/csr/don/2009_09_25/en/index.html]
- Lau JT, Yeung NC, Choi KC, Cheng MY, Tsui HY, Griffiths S: Acceptability of A/H1N1 vaccination during pandemic phase of influenza A/H1N1 in Hong Kong: population based cross sectional survey. BMJ. 2009, 339: b4164-10.1136/bmj.b4164.PubMedPubMed CentralView ArticleGoogle Scholar
- European Medicine Agency, EMEA. [http://www.emea.europa.eu/]
- Riddiough MA, Willems JS, Sanders CR, Kemp K: Factors affecting the use of vaccines: considerations for immunization program planners. Public Health Rep. 1981, 96 (6): 528-535.PubMedPubMed CentralGoogle Scholar
- WHO recommendations on pandemic (H1N1) 2009 vaccines. [http://www.who.int/csr/disease/swineflu/notes/h1n1_vaccine_20090713/en/index.html]
- Al-Otaibi BM, El-Saed A, Balkhy HH: Influenza vaccination among healthcare workers at a tertiary care hospital in Saudi Arabia: Facing challenges. Ann Thorac Med. 5 (2): 120-121.Google Scholar
- Esposito S, Bosis S, Pelucchi C, Tremolati E, Sabatini C, Semino M, Marchisio P, della Croce F, Principi N: Influenza vaccination among healthcare workers in a multidisciplinary University hospital in Italy. BMC Public Health. 2008, 8: 422-10.1186/1471-2458-8-422.PubMedPubMed CentralView ArticleGoogle Scholar
- Nichol KL, Lind A, Margolis KL, Murdoch M, McFadden R, Hauge M, Magnan S, Drake M: The effectiveness of vaccination against influenza in healthy, working adults. N Engl J Med. 1995, 333 (14): 889-893. 10.1056/NEJM199510053331401.PubMedView ArticleGoogle Scholar
- Chor JS, Ngai KL, Goggins WB, Wong MC, Wong SY, Lee N, Leung TF, Rainer TH, Griffiths S, Chan PK: Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys. BMJ. 2009, 339: b3391-10.1136/bmj.b3391.PubMedPubMed CentralView ArticleGoogle Scholar
- Balkhy HH, Abolfotouh MA, Al-Hathlool RH, Al-Jumah MA: Awareness, attitudes, and practices related to the swine influenza pandemic among the Saudi public. BMC Infect Dis. 10: 42-10.1186/1471-2334-10-42.Google Scholar
- Retailliau HF, Curtis AC, Storr G, Caesar G, Eddins DL, Hattwick MA: Illness after influenza vaccination reported through a nationwide surveillance system, 1976-1977. Am J Epidemiol. 1980, 111 (3): 270-278.PubMedGoogle Scholar
- Esposito S, Tremolati E, Bellasio M, Chiarelli G, Marchisio P, Tiso B, Mosca F, Pardi G, Principi N: Attitudes and knowledge regarding influenza vaccination among hospital health workers caring for women and children. Vaccine. 2007, 25 (29): 5283-5289. 10.1016/j.vaccine.2007.05.011.PubMedView ArticleGoogle Scholar
- Seale H, McLaws ML, Heywood AE, Ward KF, Lowbridge CP, Van D, Gralton J, MacIntyre CR: The community's attitude towards swine flu and pandemic influenza. Med J Aust. 2009, 191 (5): 267-269.PubMedGoogle Scholar
- Balkhy HH, El-Saed A, Sallah M: Epidemiology of H1N1 (2009) influenza among healthcare workers in a tertiary care center in Saudi Arabia: a 6-month surveillance study. Infect Control Hosp Epidemiol. 31 (10): 1004-1010. 10.1086/656241.Google Scholar
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