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Table 3 Risk of death from breast cancer in high staining intensity groups compared to low staining intensity groups

From: Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer

  

Log Rank test

Unadjusted HR (95% CI)

Multivariate adjusted* HR (95% CI)

COX-2

TP

P = 0.322

0.6 (0.2-1.7), P = 0.339

0.6 (0.2-2.2), P = 0.485

 

SP

P = 0.020

3.9 (1.1-14.2), P = 0.036

3.5 (0.8-14.7), P = 0.059

 

TM

P = 0.074

2.3 (0.8-6.9), P = 0.121

1.5 (0.4-6.0), P = 0.592

 

SM

P = 0.003

6.8 (1.5-30.4), P = 0.013

8.3 (4.2-27.7), P 0.024

TGF-β

TP

P = 0.984

1.0 (0.3-2.8), P = 0.989

2.2 (0.6-8.8), P = 0.249

 

SP

P = 0.839

1.1 (0.4-3.3), P = 0.842

5.2 (1.1-24.0), P = 0.035

 

TM

P = 0.052

0.4 (0.1-4.1), P = 0.069

1.4 (0.3-6.6), P = 0.701

 

SM

P = 0.032

3.0 (1.0-9.2), P = 0.046

2.3 (0.7-8.0), P = 0.174

IL-10

TP

P = 0.130

2.2 (0.8-6.4), P = 0.149

5.2 (1.3-20.6), P = 0.018

 

SP

P = 0.384

1.7 (0.5-5.3), P = 0.400

1.1 (1.0-1.8), P = 0.003

 

TM

P = 0.009

5.7 (1.3-25.6), P = 0.023

4.7 (0.8-25.5), P = 0.076

 

SM

P = 0.035

4.4 (1.0-19.7), P = 0.053

4.0 (0.8-20.7), P = 0.057

Ki67

TP

P = 0.257

1.8 (0.6-5.3), P = 0.275

1.2 (0.3-4.7), P = 0.771

 

SP

P = 0.369

1.7 (0.5-6.1), P = 0.387

1.1 (0.2-6.5), P = 0.959

 

TM

P = 0.001

7.7 (1.7-35.2), P = 0.008

7.4 (1.4-33.3), P = 0.020

 

SM

P < 0.000

3.6 (1.0-12.9), P = 0.031

1.1 (1.0-1.8), P = 0.002

  1. *Adjusted for age, histology (grade 1, 2 and 3, tumor size, oestrogen- and progesterone receptor positivity (yes/no).
  2. Abbreviations: TP: tumor cell areas of primary tumors; SP: tumor stromal areas of primary tumors; TM: tumor cell areas of metastases; SM: tumor stromal areas of metastases