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Figure 2 | BMC Research Notes

Figure 2

From: Normal X-inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice-a model of human Filamin A (FLNA) diseases

Figure 2

Quantitative comparison of heterozygous FlnaDilp2/+and wild-type Flna+/+X-inactivation mosaics. (A) Percentage of β-gal-positive cells in corneal epithelia from FlnaDilp2 and WT (Flna+/+) X-inactivation mosaics at 15 and 30 weeks. (Individual values were means of left and right eyes of each mouse.) There were no significant differences between genotypes or ages by 2-way ANOVA. (B) Corrected stripe numbers in corneal epithelia from FlnaDilp2/+and WT X-inactivation mosaics at 15 and 30 weeks. (Individual values were means of left and right eyes of each mouse.) Statistical analysis showed significant differences between both ages (P = 0.040) and genotypes (P = 0.024) by 2-way ANOVA. However, neither age nor genotype differences were significant for individual pairwise comparisons when analysed separately by Bonferroni post-hoc tests. (C) Percentage of β-gal-positive cells in livers from FlnaDilp2/+and WT X-inactivation mosaics at 3, 6 and 15 weeks. There were no significant differences between genotypes or ages by 2-way ANOVA. In each case the results are presented as mean ± SEM and the number of mice is shown above each bar.

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