Figure 4

Phylogenetic network of mtDNA harbouring m.16189 T > C. Red nodes, patients with matrilineal diabetes (N = 19); white nodes, population controls (N = 37). Cases are numbered 24–62, controls numbered as previously published [3]. The fast evolving site m.16519 and the variants in the C-tract between the positions m.303-315 were not included in the network. Outgroup, an African sequence [GenBank:AF346980]; CRS, the revised Cambridge Reference Sequence [GenBank:NC_012920]. Unless marked otherwise, mtDNA variants are transitions. Superscripts indicate transversions, inserted or deleted nucleotides: i = insertion, D = deletion, @ = back mutation. D9bp, deletion spanning between the positions m.8281 and m.8289.