Figure 2
Influence of the pedigree structure on the distribution of NPL, KC-LOD and MOD score under H 0 . Legend: Plots for the empirical distributions regarding the different pedigree sizes (P-values on a logarithmic scale). Horizontal gray lines refer to suggestive evidence for linkage (P-value of 0.0017), the classic 'LOD-3-criterion' (P-value of 0.0001), and significant evidence for linkage (P-value of 0.000049), respectively. The horizontal lines shown at the bottom of each graph represent the 95% confidence interval at the suggestive and LOD-3 level.