Table 2 Overall breast cancer risk in relation to selected SNPs
From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer
SNP Rs number (Gene) | Case/control N | Breast cancer risk Crude OR (CI 95%) | Breast cancer risk Adjusted OR* (CI 95%) | Breast cancer risk Adjusted OR** (CI 95%) |
|---|---|---|---|---|
rs2981582 (FGFR2) | ||||
CC | 233/561 | 1.00 | 1.00 | 1.00 |
CT | 356/653 | 1.31 (1.08-1.60) | 1.31 (1.07-1.60) | 1.31 (1.07-1.61) |
TT | 124/185 | 1.61 (1.23-2.12) | 1.62 (1.23-2.13) | 1.63 (1.23-2.16) |
Per allele | 1.28 (1.12-1.46) | 1.28 (1.12-1.46) | 1.28 (1.12-1.47) | |
rs1045485 (CASP8) | ||||
CC | 185/374 | 1.00 | 1.00 | 1.00 |
CG | 42/86 | 0.99 (0.66-1.49) | 0.98 (0.65-1.48) | 1.04 (0.69-1.58) |
GG | 8/10 | 1.62 (0.63-4.17) | 1.61 (0.63-4.16) | 1.73 (0.66-4.54) |
Per allele | 1.10 (0.79-1.51) | 1.10 (0.80-1.54) | 1.10 (0.79-1.54) | |
rs3803662 (TNRC9) | ||||
CC | 353/780 | 1.00 | 1.00 | 1.00 |
CT | 278/512 | 1.20 (0.99-1.46) | 1.20 (0.99-1.46) | 1.19 (0.98-1.45) |
TT | 64/95 | 1.49 (1.06-2.09) | 1.49 (1.06-2.10) | 1.47 (1.04-2.08) |
Per allele | 1.21 (1.05-1.40) | 1.21 (1.05-1.40) | 1.20 (1.04-1.39) | |
rs8051542 (TNRC9) | ||||
CC | 192/443 | 1.00 | 1.00 | 1.00 |
CT | 338/637 | 1.22 (0.99-1.52) | 1.23 (0.99-1.52) | 1.20 (0.97-1.50) |
TT | 149/272 | 1.26 (0.97-1.64) | 1.27 (0.97-1.64) | 1.24 (0.95-1.62) |
Per allele | 1.13 (1.00-1.29) | 1.13 (1.00-1.29) | 1.12 (0.99-1.28) | |
rs12443621 (TNRC9) | ||||
AA | 195/451 | 1.00 | 1.00 | 1.00 |
AG | 338/657 | 1.19 (0.96-1.47) | 1.19 (0.96-1.47) | 1.20 (0.97-1.49) |
GG | 165/275 | 1.39 (1.07-1.79) | 1.39 (1.08-1.79) | 1.42 (1.09-1.84) |
Per allele | 1.18 (1.04-1.34) | 1.18 (1.04-1.34) | 1.19 (1.04-1.35) | |
rs889312 (MAP3K1) | ||||
AA | 322/737 | 1.00 | 1.00 | 1.00 |
AC | 301/530 | 1.30 (1.07-1.58) | 1.30 (1.07-1.58) | 1.26 (1.03-1.53) |
CC | 66/118 | 1.28 (0.92-1.78) | 1.28 (0.92-1.78) | 1.29 (0.92-1.80) |
Per allele | 1.19 (1.04-1.37) | 1.19 (1.04-1.37) | 1.18 (1.02-1.36) | |
rs3817198 (LSP1) | ||||
TT | 311/668 | 1.00 | 1.00 | 1.00 |
CT | 282/555 | 1.09 (0.90-1.33) | 1.09 (0.90-1.33) | 1.06 (0.87-1.30) |
CC | 76/107 | 1.53 (1.10-2.11) | 1.53 (1.11-2.11) | 1.50 (1.08-2.09) |
Per allele | 1.18 (1.02-1.36) | 1.18 (1.02-1.36) | 1.17 (1.10-1.35) | |
rs2107425 (H19) | ||||
CC | 361/637 | 1.00 | 1.00 | 1.00 |
CT | 250/573 | 0.77 (0.63-0.94) | 0.77 (0.63-0.94) | 0.78 (0.64-0.95) |
TT | 68/145 | 0.83 (0.60-1.14) | 0.83 (0.60-1.14) | 0.83 (0.60-1.14) |
Per allele | 0.86 (0.74-0.99) | 0.86 (0.74-0.99) | 0.86 (0.75-0.99) | |
rs13281615 (8q24) | ||||
AA | 245/533 | 1.00 | 1.00 | 1.00 |
AG | 332/633 | 1.14 (0.93-1.40) | 1.14 (0.93-1.40) | 1.14 (0.93-1.40) |
GG | 117/204 | 1.25 (0.95-1.64) | 1.25 (0.95-1.64) | 1.25 (0.95-1.64) |
Per allele | 1.12 (0.98-1.28) | 1.12 (0.98-1.28) | 1.15 (1.00-1.31) | |
rs981782 (5p12) | ||||
TT | 182/335 | 1.00 | 1.00 | 1.00 |
TG | 352/685 | 0.95 (0.76-1.18) | 0.95 (0.76-1.18) | 0.91 (0.72-1.14) |
GG | 125/296 | 0.78 (0.59-1.03) | 0.78 (0.59-1.03) | 0.74 (0.56-0.98) |
Per allele | 0.89 (0.77-1.02) | 0.89 (0.77-1.02) | 0.87 (0.75-1.00) | |
rs30099 (5q) | ||||
CC | 584/1139 | 1.00 | 1.00 | 1.00 |
CT | 113/248 | 0.89 (0.70-1.13) | 0.89 (0.70-1.14) | 0.90 (0.71-1.16) |
TT | 11/12 | 1.79 (0.78-4.08) | 1.79 (0.78-4.10) | 1.79 (0.77-4.18) |
Per allele | 0.98 (0.79-1.21) | 0.98 (0.79-1.22) | 0.99 (0.80-1.24) | |
rs4666451 (2p) | ||||
GG | 272/554 | 1.00 | 1.00 | 1.00 |
GA | 299/574 | 1.06 (0.87-1.30) | 1.06 (0.87-1.30) | 1.08 (0.88-1.32) |
AA | 105/204 | 1.05 (0.80-1.38) | 1.05 (0.79-1.38) | 1.06 (0.80-1.40) |
Per allele | 1.03 (0.91-1.18) | 1.03 (0.91-1.18) | 1.04 (0.91-1.19) | |
rs13387042 (2q35) | ||||
AA | 192/335 | 1.00 | 1.00 | 1.00 |
AG | 330/657 | 1.08 (0.86-1.36) | 1.08 (0.86-1.35) | 1.08 (0.86-1.37) |
GG | 163/350 | 1.23 (0.95-1.59) | 1.23 (0.95-1.59) | 1.24 (0.96-1.62) |
Per allele | 0.90 (0.79-1.03) | 0.90 (0.79-1.03) | 0.90 (0.79-1.02) | |
rs7766585 (ESR1) | ||||
CC | 518/1031 | 1.00 | 1.00 | 1.00 |
CT | 172/348 | 0.98 (0.80-1.22) | 0.98 (0.80-1.22) | 0.98 (0.79-1.21) |
TT | 17/26 | 1.30 (0.70-2.42) | 1.30 (0.70-2.42) | 1.42 (0.76-2.67) |
Per allele | 1.03 (0.86-1.23) | 1.03 (0.86-1.23) | 1.03 (0.86-1.24) |