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Figure 1 | BMC Research Notes

Figure 1

From: Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans

Figure 1

Position of amplicons within the analysed genomic region (A) and methylation status of CpG islands (B-E) of the human CXCL2 gene. A, The genomic region of the CXCL2 gene is located from −365 to +450 relative to the gene start. This refers to position 74964548–74965362 of the NCBI’s human genome build 37.1. The gene is shown in its transcripted orientation and locates on the sense strand of chromosome 4. Colors illustrate position of the gene (blue), mRNA (green), region for amplicon design (orange), amplicons (yellow) and annotated (Ensembl) regulatory region (pink). B-E, Colored dots indicate the methylation ratio (%) at each analyzed CpG-unit within each amplicon. Samples are indicated as H-1 to H-5 (time point T0) and H-1_1 to H-5_1 (T14). Base count (upper ruler scale) and CpG-site numbering (lower ruler scale) refers to the analyzed strand in 5’→3’ orientation of the analyzed amplicon sequence. Sample “nc_001” represents the reaction negative control (water) and “con42” a control DNA.

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