ENU-induced phenovariance in mice: inferences from 587 mutations

BMC Research Notes

Table 2 Mutation types generated by ENU

	Phenotypic							Incidental
	Autosomal recessive	X-linked recessive	Autosomal dominant (or semidominant)	X-linked dominant	Unknown	Total	% of total	Homozygotes	Heterozygotes	Total	% of total
Missense	63	6	35	1	6	111	62.1	130	200	330	82.0
Noncritical splice donor site	4	0	0	0	1	5	2.8	9	13	22	5.5
Noncritical splice acceptor site	5	0	1	0	0	6	3.4	13	9	22	5.5
Nonsense ^†	27	1	5	1	1	35	19.8	7	12	19	4.7
Critical splice donor site ^†	17	0	0	0	0	17	26.6	4	4	8	2.0
Critical splice acceptor site ^†	3	0	1	0	0	4	2.2	0	1	1	0.3
Total	119*	7	42**	1	8	178		163	239	402

†Mutations considered to be overt nulls.
*Large deletions (3 alleles), small insertions (2 alleles), and a dinucleotide substitution (1 allele) were not included in the total.
**A small deletion (1 allele) was not included in the total.

ISSN: 1756-0500