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Table 1 Features of included patients. VL: viral load. HAART: highly active antiretroviral therapy

From: Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study

Variable

Number of patients (percentage), except where specified

Median age (range)

37 years (23–63)

Male gender

45 (68)

Risk category

 Injection drug users

28(42)

 Men who have sex with men

16 (24)

 Heterosexual

22 (34)

Toxic habits

Current smoking

46 (69)

Alcholism

22 (33)

Methadone Maintenance Treatment

20 (30)

Median time since diagnosis of HIV infection (range)

10 years (2–16)

CDC category

 A

54 (82)

 B

6 (9)

 C

6 (9)

Number of previous antiretroviral regimens

 1

13 (20)

 2

16 (24)

 3 or more

37 (56)

Median time on HAART before interruption (range)

284 weeks (60–512)

Adherence <80% to any previous antiretroviral therapy

20 (30)

Previous virologic failure with any antiretroviral regimen

 No

53 (81)

 Yes

13 (19)

HCV coinfection

33 (50)

HBV coinfection

2 (3)

Median HIV-1 VL at diagnosis (range)

23.750 copies/mL (100–1.511.000)

Median nadir CD4+ cell count (range)

252 cells/μL (50–552)

Main reason for the interruption of HAART

 Proposed by physician

33 (50)

 Intolerance to current regimen

20 (30,3)

 Decision of the patient

10 (15,2)

 Problems for an appropriate adherence

3 (4,5)

Median CD4+ cell count at interruption (range)

745 (350–2132)