Table 2 In vitro site-directed mutagenesis of H. pylori 23S rRNA gene and geno- and phenotypes of the mutants obtained
No. of strains CLR-susceptible | Donor DNA for mutagenesis (region of the 23S rRNA gene) | No. of transformants obtained with mutation in 23S rRNA gene | Final MIC (CLR) | No. of strains showing synergy | FIC |
|---|---|---|---|---|---|
4 | A2142G | 3 (A2142G) | >16 | 0 (0%) | >2 |
A2143G | 3 (A2143G) | >16 | 3 (100%) | <0.5 |