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Table 2 In vitro site-directed mutagenesis of H. pylori 23S rRNA gene and geno- and phenotypes of the mutants obtained

From: Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin

No. of strains CLR-susceptible Donor DNA for mutagenesis (region of the 23S rRNA gene) No. of transformants obtained with mutation in 23S rRNA gene Final MIC (CLR) No. of strains showing synergy FIC
4 A2142G 3 (A2142G) >16 0 (0%) >2
  A2143G 3 (A2143G) >16 3 (100%) <0.5