Skip to main content

Table 3 Bovine PrP genotypes in 86 cattle with numbers of dosed cattle separated by BSE status

From: Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle – an update

Genotypes

Number (Frequency)

Number BSE-positive dosed

Number BSE-negative dosed

Total dosed

ORF

    

6:6 silent Q78 HET

28 (33%)

9

18

27

6:6 WT

25 (29%)

10

12

22

6:6 silent Q78 HOM

10 (12%)

4

3

7

6:5 silent Q78 HET

7 (8%)

3

4

7

6:6 silent N192 HET

5 (6%)

4

1

5

6:5 WT

4 (5%)

3

0

3

6:6 silent Q78 HET & silent N192 HET

3 (3%)

0

1

1

6:5 silent N192 HET

2 (2%)

0

2

2

5:5* WT

1 (1%)

1

0

1

6:6 silent P113 HET

1 (1%)

1

0

1

Promoter

    

23 bp +/− 12 bp +/−

31 (38%)

12

17

29

23 bp −/− 12 bp −/−

27 (33%)

10

12

22

23 bp +/+ 12 bp +/+

10 (12%)

5

3

8

23 bp +/− 12 bp +/+

8 (10%)

3

4

7

23 bp −/− 12 bp +/−

5 (6%)

3

2

5

23 bp −/− 12 bp +/+

1 (1%)

1

0

1

  1. Genotypes 5:5, 6:6 and 6:5 refer to the copies of octapeptide repeats, 23 bp and 12 bp are the indels (− = deletion allele, + = insertion allele), Q78, P113 and N192 are silent polymorphisms, either homozygous (HOM) or heterozygous (HET) at position 78, 113 and 192 of the ORF respectively compared to the wild type (WT).
  2. Four of the 86 cattle were excluded from the comparison of the promoter region because of an inconclusive assay result for the 23-bp indel.
  3. * Exposed to 1 g in the first phase of the study and erroneously reported as having a 6:6 genotype previously [1].