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Table 1 Characteristics of patients with unfavorable cancer of unknown primary site (n = 179)

From: Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study

Characteristic

No. of patients

%

Median age at diagnosis, year (range, IQR)

73 (30-98, 58-80)

 

Gender

  

   Male

128

71.5

   Female

51

28.5

Histology

  

   Carcinoma, unclassifiable

83

46.4

   Adenocarcinoma

71

39.7

   Squamous cell carcinoma

6

3.4

   Neuroendocrine carcinoma

12

6.7

   Others

7

3.9

Histologic grade

  

   Poorly differentiated or Undifferentiated

31

17.3

   Unspecified

148

82.7

Performance status

  

   0

19

10.6

   1

67

37.4

   2

44

24.6

   3

27

15.1

   4

22

12.3

Initial site at diagnosis

  

   Liver

38

21.2

   Lung

23

12.8

   Bone

47

26.3

   Central nervous system

7

3.9

   Peritoneum

18

10.1

   Lymph nodes

43

24

   Others

3

1.7

Sites of disease involvement

  

   Liver

80

44.7

   Lung and pleural

87

48.6

   Bone

74

41.3

   Central nervous system

14

7.8

   Lymph nodes

107

59.8

No. of metastatic organs

  

   1

40

22.3

   2

52

29.1

   > 2

87

48.6

Treatment

  

   Chemotherapy

118

66.0

   Radiotherapy

52

29.1

   Tyrosine kinase inhibitors

2

1.1

Chemotherapy regimens

  

   Cisplatin-based

89

75.4

   5-FU-based

51

43.2

   Etoposide-based

45

38.1

   Gemcitabine-based

17

14.4

   Taxane-based

13

11.0

   Oxaliplatin-based

11

9.3

  1. IQR, inter-quartile range.