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Figure 5 | BMC Research Notes

Figure 5

From: TNA4OptFlux – a software tool for the analysis of strain optimization strategies

Figure 5

Manually curated variation network between the succinate producing mutant and the triple mutant (R_TKT1, R_SUCD1i and R_THD2) described in Table1. Wild-type exclusive reactions are shown in red, the ones exclusive to the mutant are in blue, while green and orange show reactions with increased or reduced flux in the mutant, respectively. Abbreviations: M_10fthf_c – 10-Formyltetrahydrofolate, M_gly_c- Glycine, M_mlthf_c- 5,10-Methylenetetrahydrofolate, M_methf_c- 5,10-Methenyltetrahydrofolate, M_nadp_c- Nicotinamide adenine dinucleotide phosphate, M_nadph_c- Nicotinamide adenine dinucleotide phosphate reduced, M_ser_L_c- L-Serine, M_succ_c- Succinate, M_thf_c- 5, 6, 7, 8-Tetrahydrofolate; R_FTHFD- formyltetrahydrofolate deformylase, R_GHMT2- Serine hydroxymethyltransferase, R_GLYCL- glycine cleavage system, R_MTHFC- 5,10-methylene-tetrahydrofolate cyclohydrolase, R_MTHFD- 5,10-methylene-tetrahydrofolate dehydrogenase, R_SSALy- succinate-semialdehyde dehydrogenase, R_SUCCt2b- succinate transporter.

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