Figure 6

Manually curated variation network between the wild-type and the glycine producing mutant described in Table2. Wild-type exclusive reactions are shown in red, the ones exclusive to the mutant are in blue, while green and orange show reactions with increased or reduced flux in the mutant, respectively. Abbreviations: M_10fthf_c- 10-Formyltetrahydrofolate, M_accoa_c- Acetyl-CoA, M_aicar_c- 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide, M_alltn_c- Allantoin, M_alltt_c- Allantoate, M_fgam_c- N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide, M_fprica_c- 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, M_gar_c- N1-(5-Phospho-D-ribosyl)glycinamide, M_glx_c- Glyoxylate, M_gly_c- Glycine, M_gly_e- Extracellular Glycine, M_gly_p- Periplasmic Glycine, M_hxan_c- Hypoxanthine, M_icit_c- Isocitrate, M_imp_c- IMP, M_ins_c- Inosine, M_mal_L_c- L-Malate, M_methf_c- 5,10-Methenyltetrahydrofolate, M_mlthf_c- 5,10-Methylenetetrahydrofolate, M_oaa_c- Oxaloacetate, M_pep_c- Phosphoenolpyruvate, M_pram_c- 5-Phospho-beta-D-ribosylamine, M_ser_L_c- L-serine, M_succ_c- Succinate, M_thf_c- 5,6,7,8-Tetrahydrofolate, M_urate_c- Urate, M_urdglyc_c- (-)-Ureidoglycolate, M_xan_c- Xanthine, R_AICART- phosphoribosylaminoimidazolecarboxamide formyltransferase, R_ALLTAMH- allantoate amidohydrolase, R_ALLTN- allantoinase, R_GARFT- phosphoribosylglycinamide formyltransferase, R_GART- GAR transformylase-T, R_GHMT2r- glycine hydroxymethyltransferase, R_GLYCL- Glycine Cleavage complex, R_GLYT2pp- glycine transport in via proton symport (periplasm), R_GLYtex- Glycine transport via diffusion, R_HXAND- hypoxanthine dehydrogenase, R_ICL- Isocitrate lyase, R_IMPC- IMP cyclohydrolase, R_MALS- malate synthase, R_MDH- malate dehydrogenase, R_MTHFC- methenyltetrahydrofolate cyclohydrolase, R_MTHFD- methylenetetrahydrofolate dehydrogenase (NADP), R_NTD11- 5'-nucleotidase (IMP), R_PPC- phosphoenolpyruvate carboxylase, R_PRAGSr- phosphoribosylglycinamide synthase, R_PUNP5- purine-nucleoside phosphorylase (Inosine), R_UGLYCH- Ureidoglycolate hydrolase, R_URIC- uricase, R_XAND- xanthine dehydrogenase.