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Table 1 Set of knockouts and the corresponding chemical reactions used as case study

From: TNA4OptFlux – a software tool for the analysis of strain optimization strategies

Reaction

Stoichiometric equation

Serine hydroxymethyltransferase

L-serine + tetrahydrofolate < = > glycine + 5,10-methylenetetrahydrofolate + H2O

pyridine nucleotide transhydrogenase

H+e + NADH + NADP+ = > H+c + NAD+ + NADPH

Succinate dehydrogenase

FAD+ + Succinate = > FADH2 + Fumarate

Transketolase I

D-erythrose-4-phosphate + D-xylulose-5-phosphate < = > D-fructose-6-phosphate + D-glyceraldehyde-3-phosphate