From: Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn’s Disease
AGE years | SEX | CONDITION | DURATION years* | CONCOMITANT THERAPIES | OVERALL RESPONSE TO TREATMENT ^ | NOTES | |
---|---|---|---|---|---|---|---|
1 | 35 | F | PD | 1.5 | Azathioprine 1yr, prednisolone | Cleared | Relapsed on stopping at 12 weeks |
2 | 27 | M | PD, MCD | 4 | Azathioprine 1yr, Prednisolone, Asacol | Two areas healed rest improved prior to exiting | Dropped out due to flare of Crohn’s |
3 | 60 | F | PG | 33 | Azathioprine 2yr, Predfoam, Asacol | Improved | Dropped out - intolerable pain from ointment |
4 | 65 | F | PD | 10 | Nil | Improved | Relapsed on stopping at 12 weeks |
5 | 33 | M | GC | 12 | Nil | Improved initially, worsened during extension | Relapsed on stopping at 12 weeks |
6 | 37 | F | GC | 5 | Prednisolone | Improved | Less frequent and severe swelling. |
7 | 20 | M | PD | 3 | Azathioprine 5yr, Methotrexate | Improved | Dropped out - severe flare of systemic disease |
8 | 12 | M | GC | 5 | Nil | Moderate improvement | Relapsed on stopping at 12 weeks |
9 | 32 | M | MCD | 4 | Azathioprine 2yr | No change | |
10 | 66 | M | PD | 1.5 | Nil | Initial improvement | Relapsed on stopping at 12 weeks |
11 | 42 | M | PD | 17 | Nil | Improved | |
12 | 16 | M | GC | 13 | Nil | Mild improvement | Relapsed on stopping at 12 weeks |
13 | 56 | F | PD | 15 | Asacol, Predfoam | Moderate improvement | Relapsed on stopping at 12 weeks |
14 | 29 | F | PD | 1.5 | Nil | No change | |
15 | 35 | M | PD | 0.75 | Nil | Pronounced improvement | Relapsed on stopping at 12 weeks |
16 | 63 | F | PG, PD | 6 | Nil | Pronounced improvement | Systemic disease flared week 9 |
17 | 33 | M | PD | 5 | Nil | Skin healed at 8 weeks but pain continued | Exited trial at week 8 |
18 | 15 | M | GC | 10 | Nil | Moderate improvement of lip swelling | Fewer mouth ulcers, relapsed |
19 | 30 | M | PD, MCD | 25 | Nil | Cleared | |
20 | 38 | F | PPG | 1.5 | Prednisolone, methotrexate, infliximab | Pronounced improvement | Relapsed on stopping at 12 weeks |