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Table 5 Summary of homologous domains between humans and forty-one mononegaviruses

From: Domain analysis of symbionts and hosts (DASH) in a genome-wide survey of pathogenic human viruses

Pfam domain

Domain name

Function

Viral

Human

Human homologs

E-value range

Median domain coverage

E-value range

Median domain coverage

Human seq. hits per virus

PF06407

Borna disease virus P40

Target for MHC class I-restricted cytotoxic T-cell response

2.4e-266 - 2.4e-266

1.00

4.6e-7 - 2.5e-77

0.52

6

Endogenous, Bornavirus-like nucleoprotein 1,

Endogenous Bornavirus-like nucleoprotein 2

PF01728

FtsJ-like methyltransferase

Methyltransferase

7.8e-4 - 1.8e-6

0.52

6.6e-6 - 2.4e-66

0.65

43

Many c

PF14314

Virus-capping methyltransferase

Virus-capping methyltransferase

4.1e-84 - 2.9e-106

0.98

5.1e-04 - 5.1e-04

0.10

1

Hypothetical protein

PF00642

Zinc finger

Mediates binding specificity

4.5e-05 - 4.5e-05

0.89

1.0e-3 - 6.5e-13

0.93

294

Many c

PF12803 a

mRNA methyltransferase

Cap methylation of mRNA.

9.0e-93 - 4.6e-117

1.00

1.4e-4 - 2.5e-4

0.37

3

Putative ADP-ribosylation factor-like protein 5C, hCG31412, isoform CRA_a, hCG31412, isoform CRA_b

PF00429 a

ENV polyprotein (coat polyprotein)

Coat polyprotein

1.0e-03 - 1.0e-03

0.17

9e-4 - 1.6e-68

0.27

51

Many c

PF00523b

Fusion glycoprotein (F0)

Viral attachement

7.4e-96 – 8.8e-189

1.00

1.4e-64 - 1.4e-64

0.44

1

Angrgm-52

PF00661 b

Viral matrix protein (M)

Viral assembly

4.1e-84 – 2.3e-146

0.99

2.9e-106 - 2.9e-106

0.37

1

Angrem52

PF14313 b

N-terminal Paramyxovirinae phosphoprotein (P)

Phosphoprotein

4e-4 - 2e-26

0.95

1.4e-21 - 1.4e-21

0.98

1

AngRem104

PF13825 b

N-terminal Paramyxovirus structural protein (V/P)

Structural protein

7.6e-4 - 5.4e-153

0.75

2.2e-4 - 2.2e-4

0.42

1

AngRem104

  1. a Similarities with weaker evidence (i.e. high E-values, low domain coverage, numerous human sequence hits).
  2. b Similarities likely resulting from mis-annotation of human sequences.
  3. c Refer to http://tinyurl.com/spouge-dash for detailed lists of the similarity hits for individual viruses.