Characteristics | Training cohort | Verification |
---|---|---|
Ā | (nā=ā213) | cohort (nā=ā211) |
Age at biopsy in years, meanāĀ±āSD | 44.4āĀ±ā11.8 | 45.6āĀ±ā11.4 |
Male, n (%) | 179 (84) | 175 (83) |
Biopsy | Ā | Ā |
Necroinflammation score, meanāĀ±āSD | ||
āāPeriportal inflammation | 1.0āĀ±ā0.8 | 0.9āĀ±ā0.8 |
āāConfluence necrosis | 0.3āĀ±ā1.0 | 0.2āĀ±ā0.8 |
āāFocal inflammation | 1.9āĀ±ā0.7 | 2.0āĀ±ā0.7 |
āāPortal inflammation | 2.2āĀ±ā1.0 | 2.2āĀ±ā0.9 |
ISHAK fibrosis score, n (%) | Ā | Ā |
āā0 | 1 (1) | 1 (1) |
āā1 | 28 (13) | 28 (13) |
āā2 | 32 (15) | 32 (15) |
āā3 | 70 (33) | 71 (34) |
āā4 | 21 (10) | 21 (10) |
āā5 | 46 (22) | 45 (21) |
āā6 | 15 (7) | 13 (6) |
HBeAg-positive, n (%) | 109 (51) | 91 (43) |
Biochemistry, meanāĀ±āSD | Ā | Ā |
AST (IU/mL) | 91.3āĀ±ā83.6 | 94.9āĀ±ā100.1 |
ALT (IU/mL) | 170.1āĀ±ā173.8 | 166.2āĀ±ā177.9 |
AST/ALT | 0.6āĀ±ā0.3 | 0.6āĀ±ā0.3 |
AFP (ng/mL) | 10.5āĀ±ā22.2 | 20.4āĀ±ā82.0 |
Bilirubin (mg/dL) | 1.0āĀ±ā0.7 | 1.0āĀ±ā0.4 |
GGT (IU/L) | 69.0āĀ±ā77.0 | 60.1āĀ±ā57.3 |
Albumin (g/dL) | 4.6āĀ±ā0.3 | 4.5āĀ±ā0.4 |
Platelet (Ć103/mm3) | 188.2āĀ±ā54.2 | 189.2āĀ±ā49.4 |
Prothrombin time prolongation (sec) | 1.0āĀ±ā0.6 | 1.0āĀ±ā0.8 |
White blood cell (Ć103/mm3) | 5.7āĀ±ā1.7 | 5.5āĀ±ā1.6 |
Hemoglobin (g/dL) | 15.1āĀ±ā1.4 | 15.2āĀ±ā1.3 |
Alpha-1 globulin (g/dL) | 0.2āĀ±ā0.1 | 0.2āĀ±ā0.0 |
Alpha-2 globulin (g/dL) | 0.8āĀ±ā0.2 | 0.8āĀ±ā0.1 |
Beta globulin (g/dL) | 0.8āĀ±ā0.1 | 0.7āĀ±ā0.1 |
Gamma globulin (g/dL) | 1.5āĀ±ā0.4 | 1.4āĀ±ā0.4 |
Albumin/Globulin | 1.5āĀ±ā0.3 | 1.5āĀ±ā0.3 |