Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence

Table 1 Potencies of drugs to block DA uptake or methamphetamine-induced DA release

	DA uptake	Methamphetamine-induced DA release
	IC₅₀ (μM) (95% CI)	IC₅₀ (μM) (95% CI)
Methamphetamine	1.05 (0.7-1.5)	-
Bupropion	1.76 (1.1-2.8)	14.2 (9.7-21)
Methylphenidate	0.14 (0.1-0.2)	1.67 (0.7-4.0)
MDPV	0.031(0.03-0.04)	0.28 (0.1-0.6)

Values are means of 3–4 independent experiments and 95% confidence intervals (CI).

ISSN: 1756-0500