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Table 4 Allele frequencies of the IL10 polymorphisms according to the Crohn’s disease phenotypes

From: Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease

   

rs1800896

  

rs1800871*

  
   

AlleleG

   

Allele T

  
 

N

n (%)

OR

P B

P value

n (%)

OR

P B

P value

   

[99.83 CI]

   

[99.83 CI]

  

• Age at diagnosis

         

A1

12

16 (66.7)

4.32

0.006

0.001

6 (25)

0.54

1.000

0.260

   

[1.0022 – 8.62]

   

[0.07 - 2.59]

  

A2 + A3

79

50 (31.6)

   

60 (38)

   

• Behavior

         

B1

62

42 (33.9)

0.68

1.000

0.316

47 (37.9)

1.4

1.000

0.401

   

[0.23 - 2.05]

   

[0.46 - 4.58]

  

B2 + B3

28

24 (42.9)

   

17 (30.4)

   

P

40

30 (37.5)

1.07

1.000

0.877

48 (60)

7.77

< 0.0001

< 0.0001

   

[0.38 - 2.96]

   

[2.53 - 26.90]

  
  1. A1 ≤ 16 years, A2 17–40 years, A3 > 40 years, B1 Non-stricturing, non-penetrating, B2 Stricturing, B3 Penetrating, P Perianal disease modifier.
  2. N Number of patients, n (%) Number of alleles (percent), PB Bonferroni adjustment.
  3. *SNPs rs1800871 and rs1800872 were in 100% linkage disequilibrium.