Ectopic acromegaly due to a GH-secreting pituitary adenoma in the sphenoid sinus: a case report and review of the literature

Table 2 Reported cases of ectopic GH-secreting adenomas

Author	Bioch. Dx	Ectopic location	Pituitary	Dura	Sellar floor	IHC
Corenblum, [17]	GH 46.8 ng/mL	Sphenoid sinus	Normal	Intact	Intact	GH++
Corenblum, [17]	PRL 5 ng/mL
Warner, [13]	---	Sphenoid sinus	Normal	Intact	Erosion	GH++
Warner, [13]						PRL+
Maddona, [14]	---	Sphenoid sinus	Normal	Intact	Erosion	GH++
Maddona, [14]						TSH+
Matsuno, [15]	GH 97 ng/mL	Sphenoid sinus	Empty sella	Intact	Absent	GH++
	IGF-1 2.3 x ULN					PRL+
	PRL 140 ng/mL					α-SU+
Hori, [16]	GH 14.5 ng/mL	Sphenoid sinus	Empty sella	Defect.	Absent	GH++
Hori, [16]	PRL 26.3 ng/mL
Mitsuya, [9]	GH 133 ng/mL	Cavernous sinus	Normal	Intact	Intact	GH++
Mitsuya, [9]	PRL 73 ng/mL					PRL+
Gondim, [18]	GH 97 ng/mL	Sphenoid sinus	Empty sella	Intact	Absent	GH++
	IGF-1 2.7 x ULN
	PRL 17 ng/mL
Chan, [10]	---	Sphenoid sinus	Normal	Intact	Intact	---
Bhatoe, [12]	GH 36 ng/mL	Clivus	Normal	Defect.	Erosion	GH++
						PRL+
						LH+
						FSH+
Guerrero, [11]	GH 12.3 ng/mL	Sphenoid sinus	Normal	Intact	Intact	GH++
	IGF-1 1.9 x ULN
	PRL 40.2 ng/mL					PRL+
Kurowska, [19]	GH 4.3 ng/mL	Sphenoid sinus	Empty sella	?	?	GH++
Kurowska, [19]	IGF-1 2.5 x ULN
Appel, [8]	GH 6 ng/mL	Clivus	Empty sella	Intact	Intact	GH++
	IGF-1 3.1 x ULN					PRL+
	PRL 26 ng/mL
Hong, [3]	GH 18 ng/mL	Sphenoid sinus	Empty sella	Intact	Partially absent	GH++
Hong, [3]	IGF-1 3.6 x ULN
Current case	GH 7.7 ng/mL	Sphenoid sinus	Empty sella	Intact	Intact	GH++
Current case	IGF-1 4.8 x ULN					PRL+
	PRL 12.7 ng/mL

ISSN: 1756-0500