Table 1 ^Cancer Gene Census [27] information for the dysregulated hubs identified in the melanoma cancer dataset
Symbol | CCND2 | CCND3 | FANCA | FANCD2 | GATA2 | KIF5B | LMO2 | RET | VHL | WAS |
|---|---|---|---|---|---|---|---|---|---|---|
P-value | 0.04 | 0.033 | 0.021 | 0.036 | 0.015 | 0.047 | 0.016 | 0.001 | 0.019 | 0.01 |
Name | cyclin D2 | cyclin D3 | Fanconi anemia, complementation group A | Fanconi anemia, complementation group D2 | GATA binding protein 2 | kinesin family member 5B | LIM domain only 2 (rhombotin-like 1) (RBTN2) | ret proto-oncogene | von Hippel-Lindau syndrome gene | Wiskott-Aldrich syndrome |
Gene ID | 894 | 896 | 2175 | 2177 | 2624 | 3799 | 4005 | 5979 | 7428 | 7454 |
Chr | 12 | 6 | 16 | 3 | 3 | 10 | 11 | 10 | 3 | X |
Chr Band | 12p13 | 6p21 | 16q24.3 | 3p26 | 3q21.3 | 10p11.22 | 11p13 | 10q11.2 | 3p25 | Xp11.23-p11.22 |
Cancer Somatic Mut | yes | yes | NA | NA | yes | yes | yes | yes | yes | NA |
Cancer Germline Mut | NA | NA | yes | yes | NA | NA | NA | yes | yes | NA |
Tumour Types Somatic Mutations | NHL,CLL | MM | NA | NA | AML(CML blast transformation) | NSCLC | T-ALL | medullary thyroid, papillary thyroid, pheochromocytoma, NSCLC | renal, hemangioma, pheochromocytoma | NA |
Tumour Types Germline Mutations | NA | NA | AML, leukemia | AML, leukemia | NA | NA | NA | medullary thyroid, papillary thyroid, pheochromocytoma | renal, hemangioma, pheochromocytoma | lymphoma |
Cancer Syndrome | NA | NA | Fanconi anaemia A | Fanconi anaemia D2 | NA | NA | NA | Multiple endocrine neoplasia 2A/2B | von Hippel-Lindau syndrome | Wiskott-Aldrich syndrome |
Tissue Type | L | L | L | L | L | E | L | E, O | E, M, O | L |
Cancer Molecular Genetics | Dom | Dom | Rec | Rec | Dom | Dom | Dom | Dom | Rec | X-linked recessive |
Mutation Type | T | T | D, Mis, N, F, S | D, Mis, N, F | Mis | T | T | T, Mis, N, F | D, Mis, N, F, S | Mis, N, F, S |
Translocation Partner | IGL@ | IGH@ | NA | NA | NA | RET, ALK | TRD@ | H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6 | NA | NA |
Other Germline Mut | NA | NA | NA | NA | NA | NA | NA | yes | NA | NA |
Other Syndrome Disease | NA | NA | NA | NA | NA | NA | NA | Hirschsprung disease | NA | NA |