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Table 3 IC 50 values of telaprevir on transport activity by P-gp or BCRP

From: Biochemical interaction of anti-HCV telaprevir with the ABC transporters P-glycoprotein and breast cancer resistance protein

 

Substrate

IC50of telaprevir (μmol/L)

P-gp

VCR

7

BCRP

E1S

30

 

MTX

31