Figure 1

Plasma concentrations of fenretinide and its metabolites, concomitant ceftriaxone and acetaminophen, and laboratory analysis in patient. A) Plasma concentrations of fenretinide (closed circle) and the metabolites (4-MPR: open circle and 4-oxo-4-HPR: filled triangle) versus time after the initiation of infusion (hr) is plotted. Each dose of ceftriaxone (750 mg/dose), and acetaminophen (10 mg/kg for the initial dose and 15 mg/kg for subsequent doses) is indicated. B) Liver function analysis, AST/ALT, bilirubin (maximum for that date), and PT, are plotted on the same time scale. Due to the differences in values, the left Y-axis was used for plotting AST and ALT, and right Y-axis was used for bilirubin and PT. A PT value at 40 hours was not available.