DNA methylation signatures in cord blood associated with maternal gestational weight gain: results from the ALSPAC cohort

Table 1 Characteristics of the study populations from the ALSPAC cohort

	Discovery & Validation sample (n = 88)^†	Replication sample (n = 170)	Rest of eligible (n = 1991)^§
Child’s sex, male (%)	51.1	50.6	49.5
Age of mother at birth, mean (sd)	30.6 (3.3)	28.7 (4.4)	27.4 (5.1)
Maternal pre-pregnancy BMI (kg/m ² )
Mean (sd)	22.2 (3.05)	23.8 (4.1)	23.1 (3.9)
Normal, 18.5-24.9, (%)	85.9	68.6	73.6
Underweight, < 18.5, (%)	1.2	2.4	4.8
Overweight, 25.0-29.9, (%)	10.6	20.7	15.5
Obese, ≥ 30, (%)	2.4	8.3	6.1
GWG (kg/wk)
0 to 18 weeks
Mean (sd)	0.32 (0.17)	0.31 (0.18)	0.30 (0.18)
Median	0.33	0.32	0.31
Min, Max	-0.33, 0.83	-0.22, 0.79	-0.64, 1.31
19-28 weeks
Mean (sd)	0.55 (0.17)	0.54 (0.16)	0.53 (0.18)
Median	0.55	0.53	0.53
Min, Max	0.22, 1.00	0.14, 0.96	-0.18, 1.45
29 weeks onwards
Mean (sd)	0.49 (0.18)	0.47 (0.20)	0.46 (0.21)
Median	0.47	0.45	0.45
Min, Max	-0.02, 0.95	0.03, 1.04	-0.54, 1.22
IoM categories, (%)
Recommended	36.6	37.3	36.1
Less than recommended	34.1	31.9	35.8
More than recommended	29.3	30.8	28.1

^†4 subjects initially included in the discovery study (n = 88) failed in the validation study.
^§Participants of the ALSPAC cohort with available cord blood DNA.

ISSN: 1756-0500