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Figure 3 | BMC Research Notes

Figure 3

From: CDK9 inhibition strategy defines distinct sets of target genes

Figure 3

Very limited correlation among genes modulated by siCDK9 and dnCDK9 in hTERT immortalized NHF. (A) Knockdown of CDK9 results in reduced cyclin T1 expression, but does not affect RNAPII phosphorylation noticeably. The Coomassie Blue stained membrane is shown as loading control. NT indicates untransfected cells and scr indicates scramble siRNA. (B) log2 expression ratios for transcripts which levels changed a +/-1 log2 ratio or more with siCDK9 (103 and/or 104 vs. scr) or dnCDK9 (DN vs. tet/DN) expression were hierarchically clustered using Cluster 3.0 (correlation uncentered, average linkage)(~650 transcripts are shown). The correlation among arrays is show on top. A heat map legend is shown.

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