Mechanic’s hands revisited: is this sign still useful for diagnosis in patients with lung involvement of collagen vascular diseases?

Table 1 Clinical features of patients with mechanic’s hands reported previously and the present four patients

Year	Age (y)	Sex	Gottron’s sign	Heliotrope rash	Shawl sign	V-neck sign	Raynaud’s	Periungual erythema	Myalgia or weakness	Auto-antibody	Diagnosis	IP	Ref
1994	69	F	-	-	-	-	-	-	+	Jo-1	DM	+	[2]
1996	7	M	+	-	-	-	+	+	+	ANA, ds-DNA, RF	SDM	N.A	[3]
2000	67	M	+	+	+	+	-	+	-	-	DM	+	[4]
2001	42	M	+	-	-	-	-	-	+	ANA	DM	-	[5]
2002	41	M	-	+	-	-	+	-	+	Jo-1	Anti-ARS synd	+	[6]
2002	40	F	-	+	-	-	-	-	+	Jo-1	Anti-ARS synd	+	[6]
2002	30	M	-	+	-	-	-	-	-	Jo-1	Anti-ARS synd	+	[6]
2003	48	F	-	-	-	-	-	+	-	RNP	RA	+	[7]
2003	55	M	+	+	-	-	-	-	-	Jo-1, RNP	DM	+	[7]
2003	29	F	-	-	-	-	-	-	-	Jo-1	DM	+	[7]
2004	56	F	+	-	-	-	-	-	-	PM-SCL	SDM	+	[8]
2005	62	F	+	-	-	-	-	-	-	PL-7	DM	+	[9]
2005	59	F	-	-	-	-	+	-	+	Jo-1	Anti-ARS synd	+	[10]
2006	30	M	+	+	-	-	+	-	-	PL-7	Anti-ARS synd	+	[11]
2007	41	M	+	-	-	+	-	-	-	Jo-1	Anti-ARS synd	+	[12]
2007	37	F	-	-	-	-	+	-	+	Jo-1	Anti-ARS synd	+	[13]
2007	73	F	-	-	-	-	+	-	-	Jo-1	Anti-ARS synd	+	[13]
2007	49	F	-	-	-	+	-	-	-	Jo-1	Anti-ARS synd	+	[13]
2008	56	F	-	-	-	-	-	-	-	ANA, Jo-1, SS-A	Anti-ARS synd	+	[14]
2009	56	M	+	-	-	-	-	+	-	PL-7	DM	+	[15]
2009	64	F	+	-	+	-	-	+	+	-	DM	+	[15]
2009	44	F	+	-	-	-	-	+	-	ANA	DM	-	[15]
2009	56	M	-	+	-	-	-	+	+	ANA	DM	+	[15]
2009	65	F	-	+	-	-	-	+	+	ANA	DM	+	[15]
2010	54	F	-	-	-	-	-	-	-	OJ	Anti-ARS synd	+	[16]
2010	67	F	-	-	-	-	-	+	-	SS-A, Jo-1	Anti-ARS synd	+	[17]
2010	48	F	+	-	-	-	+	+	-	SS-A, Jo-1, ASMA	Anti-ARS synd	+	[18]
2011	64	F	-	-	-	-	+	-	+	Jo-1	Anti-ARS synd	+	[19]
2011	43	M	-	-	-	-	-	-	+	Jo-1	Anti-ARS synd	+	[20]
2012	21	M	-	-	-	-	+	-	+	PL-12	Anti-ARS synd	+	[21]
2012	79	M	-	-	-	-	-	-	+	Jo-1	Anti-ARS synd	+	[22]
Case 1	51	M	+	-	+	+	-	+	+	CADM-140	ADM	+
Case 2	71	M	+	-	-	-	-	+	-	Jo-1	ADM	+
Case 3	31	M	+	-	-	-	-	+	+	CADM-140, AQP-4	DM	+
Case 4	77	M	+	+	+	+	-	+	+	ANA	DM	-

ANA: anti nuclear antibody, AQP-4: aquaporin 4, ARS: aminoacyl-transfer RNA synthetase, ASMA: anti-smooth muscle antibody, CADM: clinical amyopathic dermatomyositis, DM: dermatomyositis, ds-DNA: double strand-DNA, IP: interstitial pneumonia, NA: not available, NSIP: non specific interstitial pneumonia, OP: organizing pneumonia, PM: polymyositis, RA: rheumatoid arthritis, RF: rheumatoid factor, RNP: ribonucleoprotein, SDM: sclerodermatomyositis, UIP: usual interstitial pneumonia.

ISSN: 1756-0500