Chromogranins can be measured in samples from cats and dogs

BMC Research Notes

Table 1 Assays used for the cross reactivity studies in adrenal extracts from cat

Assay	MV	SD	CV	Suitable assay	Aa homology
CGA 17-38	3,26	0,16	4,8%	Yes	100%
CGA 176-195	0,14	0,02	16,7%	No	59%
CGA 238-247	0,23	0,08	35,4%	No	90%
CGA 324-337	3,04	0,88	29,0%	No	93%
CGA 361-372	1,16	0,04	3,4%	Yes	83%
SG2 154-165	3,79	0,10	2,7%	Yes	100%
CGB (Eurodiagnostica)	2,31	0,30	12,8%	Yes	85%
CGA (Eurodiagnostica)	14,63	3,23	22,1%	No

The table shows the assays used for the cross reactivity studies of Chromogranin A (CGA), Chromogranin B (CGB) and Secretogranin II (SG2) measurements in adrenal extracts from cat. A coefficient of variation (CV = SD/MV) less than 13.5% (=1.5 x assay CV) was considered acceptable for measurements i.e. determined as a suitable assay, see text for explanation. The amino acid (Aa) homology between the human and feline species is indicated for the different assays.

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