Genetic variants conferring susceptibility to Alzheimer’s disease in the general population; do they also predispose to dementia in Down’s syndrome

Table 2 Association between genetic variants and mortality

		Risk allele	All subjects (N = 233)*			Subjects with Dementia (N = 109)**			Subjects without dementia (N = 124)**
Nearest gene	SNP	A	Hazard ratio	SE	p -value	Hazard ratio	SE	p -value	Hazard ratio	SE	p -value
*CR1*	rs3818361	G	1.65	0.18	5.36 × 10^-3	2.33	0.29	4.08 × 10^-3	1.35	0.23	0.19
*BIN1*	rs744373	C	1.05	0.20	0.82	1.34	0.44	0.51	0.94	0.25	0.81
*CD2AP*	rs9349407	T	1.10	0.18	0.61	1.92	0.31	0.04	0.82	0.23	0.40
*EPHA1*	rs11767557	C	1.23	0.19	0.29	0.76	0.35	0.44	1.47	0.24	0.10
*CLU*	rs1532278	G	1.17	0.16	0.33	0.89	0.32	0.73	1.27	0.20	0.23
*MS4A6A*	rs610932	A	0.72	0.18	0.07	1.02	0.34	0.95	0.64	0.21	0.03
*PICALM*	rs561655	G	0.71	0.17	0.05	0.94	0.36	0.86	0.64	0.21	0.04
*ABCA7*	rs3764650	C	1.08	0.33	0.81	1.27	0.54	0.65	0.74	0.46	0.52
*CD33*	rs3865444	–	0.73	0.18	0.08	0.53	0.33	0.05	0.91	0.21	0.67
Genetic risk score	-		1.70	0.25	0.03	3.13	0.52	0.03	1.54	0.28	0.13

*Covariates included in the analyses were sex, intellectual disability and dementia; **Covariates included in the analyses were sex and intellectual disability.

ISSN: 1756-0500