Skip to main content

Table 1 Expression of HFD-induced genes in breast cancer subtypes and association with breast cancer prognosis

From: Analysis of high fat diet induced genes during mammary gland development: identifying role players in poor prognosis of breast cancer

Genea

Basal-likeb

HER2c

Luminal Ad

Luminal Be

Normal-likef

Survival associationg

MMP12

0.17

-0.13*

-0.24*

-0.19*

-0.33*

Poor prognosis

GPNMB

-0.01

0.00

-0.18*

-0.06

-0.11

Poor prognosis

CTSL

0.07

0.04

-0.16*

-0.03*

-0.18*

Poor prognosis

ITGAX

0.00

0.07*

0.04

0.05

0.05

-

LILRB4

0.10

0.02

-0.15*

-0.04*

-0.22*

Poor prognosis

TM7SF1

-0.18

0.05*

0.05*

0.01*

-0.03*

-

DNMT3A

0.09

0.03

-0.08*

0.00*

-0.10*

Poor prognosis

TYROBP

0.06

0.01

-0.05*

-0.01

-0.13*

-

DIO1

-0.21

-0.18

-0.04*

-0.01*

-0.07*

-

SLC11A1

0.14

0.01*

-0.10*

-0.03*

-0.15*

Poor prognosis

GALNS

0.05

0.03*

0.01

0.03

0.01

-

NCF2

0.11

0.01*

-0.15*

-0.04*

-0.16*

Poor prognosis

PTPNS1

0.23

0.00*

-0.15*

-0.08*

-0.14*

Poor prognosis

LGALS3

-0.07

0.04*

-0.03

-0.01*

0.04*

-

MTHFS

-0.02

0.00

0.02

0.05*

-0.07

-

IL1RN

0.00

-0.17*

-0.13*

-0.11

-0.05

-

CTSS

0.12

-0.04*

-0.17*

-0.06*

-0.20*

-

WBSCR5

0.03

0.01

0.00

0.00

-0.06*

-

PRKCD

-0.05

0.02*

0.03*

0.04*

-0.02

-

CAPG

0.09

-0.03*

-0.06*

0.01*

-0.07*

-

CD68

0.06

0.09

-0.02*

0.02

-0.01*

-

ITGB2

0.11

0.04

-0.09*

-0.03*

-0.11*

Poor prognosis

CSTB

0.18

0.02*

-0.04*

-0.03*

-0.07*

Poor prognosis

ATF3

0.01

-0.13*

-0.12*

-0.09*

0.01

-

CSF2RA

0.01

-0.01

-0.02

-0.01

-0.11*

-

WFS1

-0.20

0.00*

0.03*

0.06*

-0.02*

-

PPGB1

0.00

0.07*

-0.05*

0.02

-0.07*

Poor prognosis

ADAM8

0.12

0.02*

-0.09*

-0.06*

-0.25*

Poor prognosis

CCRL2

0.06

0.07

-0.01

0.02

-0.06*

-

VTN

0.00

0.00

0.01

0.01

0.06

-

RGS1

0.04

0.01

-0.03*

-0.04*

-0.13*

-

FCGR3

0.09

0.06

-0.03*

0.03*

-0.08*

Poor prognosis

EMR1

0.06

-0.03

0.01

0.00*

0.03

-

ARPC2

0.06

0.03

-0.06*

-0.03*

-0.03*

-

ESD

-0.04

-0.04

0.02*

-0.01

0.08*

Good prognosis

VAMP4

0.06

0.05

0.05

0.05

-0.03

-

CDKN1C

-0.05

-0.05

-0.05

-0.12

0.13*

-

HEXB

-0.04

0.00

-0.02

-0.02

-0.03

-

NAGLU

-0.01

0.05*

0.02

0.04*

0.12*

-

KCNH2

0.00

-0.29*

-0.21*

-0.15*

-0.32*

-

MSTF1

0.02

0.03

0.04*

0.04*

0.04

-

  1. aHFD induced genes (Luitjen et al.) that were present in the NKI human breast cancer data set as described in the Methods. b-fAverage gene expression among 5 different human breast cancer subtypes for these genes (Tumors: basal-like n = 46; HER2 n = 49; luminal A n = 88; luminal B n = 81; normal-like n = 31). gTotal of 13 genes associated with poor prognosis and 1 gene associated with good prognosis based on Kaplan Meier survival analysis for the indicated gene with 295 BC samples from the NKI dataset as described in the Materials and Methods. The plots for the genes that were significantly associated with prognosis are depicted in Figure 1 of this manuscript. *Gene expression statistically different with respect to basal-like subtype (False discovery Rate [FDR] < 0.01).
Back to article page

BMC Research Notes

ISSN: 1756-0500

Contact us