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Table 2 Cellular processes of genes associated with poor prognosis

From: Analysis of high fat diet induced genes during mammary gland development: identifying role players in poor prognosis of breast cancer

Gene

Description

GO reference

Gene ontology

Mmp12

Matrix metallopeptidase 12

GO:0006508

Proteolysis

Gpnmb

Glycoprotein (transmembrane)

GO: 0007155

Cell adhesion

Ctsl

Cathepsin L

GO:0006508

Proteolysis

Lilrb4

Leukocyte immunoglobulin-like receptor, subfamily B, member 4

GO: 0045671

Negative regulation of osteoclast differentiation

Dnmt3a

DNA (cytosine-5-)-methyltransferase 3 alpha

GO:0006306

DNA methylation

Slc11a1

Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

GO:0070839

Divalent metal ion export

Ncf2

Neutrophil cytosolic factor 2

GO:0016175

Superoxide-generating NADPH oxidase activity

Ptpns1

Signal-regulatory protein alpha

GO: 0007155

Cell adhesion

Itgb2

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

GO:0007155

Cell adhesion

Cstb

Cystatin B (stefin B)

GO:0010466

Negative regulation of peptidase activity

Ppgb1

Cathepsin A

GO: 0006508

Proteolysis

Adam8

ADAM metallopeptidase domain 8

GO: 0006508

Proteolysis

Fcgr3

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

GO:0001788

Antibody-dependent cellular cytotoxicity

  1. Gene ontologies from the AMIGO database were obtained for HFD induced genes that were found to be associated with poor prognosis.