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Table 5 Genotypic frequencies according to clinical parameters of the Moroccan UC patients investigated for the T300Apolymorphism

From: IL23R and ATG16L1 variants in Moroccan patients with inflammatory bowel disease

Clinical parameters

N

ATG16L1T300A

P value

Chi-deux test

AA

AG

GG

Age of onset

30

   

0.12

4.32

<17 years

-

     

17-40

21

10 (47.6)

8 (38.1)

3 (14.3)

  

>40 years

9

1 (11.1)

7 (77.8)

1 (11.1)

  

Sex

30

   

0.41

1.76

Woman

14

4 (28.6)

7 (50.0)

3 (21.4)

  

Man

16

7 (43.8)

8 (50.0)

1 (6.3)

  

Localization

30

   

0.71

3.73

Leftcolitis

11

5 (45.5)

5 (45.5)

1 (9.1)

  

Extensive colitis

2

-

2 (100.0)

-

  

Pancolitis

13

4 (30.8)

7 (53.8)

2 (15.4)

  

Proctitis

4

2 (50.0)

1 (25.0)

1 (25.0)

  

SFC

30

   

0.41

1.79

Presence

1

1 (100.0)

-

-

  

Absence

29

10 (34.5)

15 (51.7)

4 (13.8)

  

Smoking

30

   

0.19

3.36

Presence

8

5 (62.5)

2 (25.0)

1 (12.5)

  

Absence

22

6 (27. 3)

13 (59.1)

3 (13.6)

  

Appendectomy

30

   

0.05

6.20

Presence

-

-

-

-

  

Absence

30

11 (36.7)

15 (50.0)

4 (13.3)

  

EIM

30

   

0.50

1.38

Presence

17

7 (41.2)

7 (41.2)

3 (17.6)

  

Absence

13

4 (30.8)

8 (61.5)

1 (7.7)

  

Surgery

30

   

0.22

3.04

Presence

4

3 (75.0)

1 (25.0)

-

  

Absence

26

8 (30.8)

14 (53.8)

4 (15.4)

  
  1. (SFC: Similar familial cases; EIM: Extra intestinal manifestations; N: Total number; AA: wild type ATG16L1 T300A, AG: ATG16L1 T300A heterozygous variant, GG: ATG16L1 T300A homozygous variant).